FINAL Flashcards

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1
Q

Explain the lines of defense that the respiratory system has throughout the upper and lower respiratory tract.

A
  • Mucous cells and mucous glands
    • Produce mucus that bathes exposed surfaces
  • Cilia
    • Sweep debris trapped in mucus toward the pharynx (mucus escalator)
  • Filtration in nasal cavity removes large particles
  • Alveolar macrophages engulf small particles that reach lungs
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2
Q

identify in chronological order the flow of air through the structures of the respiratory system starting with the intake through the external nares (nose) to the alveoli.

A
  • external nares (nostrils)
  • internal nares
  • nasopharynx
  • oropharynx
  • laryngopharynx
  • larynx
  • trachea
  • primary bronchi
  • secondary bronchi
  • tertiary bronchi
  • terminal bronchi
  • respiratory bronchi
  • alveoli
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3
Q

Identify the structures that comprise the upper and lower respiratory division.

A
upper:
nose
nasal cavity
sinuses
pharynx

// larynx //

lower:
larynx
trachea
bronchus
bronchioles
alveoli
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4
Q

describe the pharynx

A

chamber shared by digestive and respiratory systems

extends from internal nares to entrances to larynx and esophagus

Divided into three parts

  • The nasopharynx
  • The oropharynx
  • The laryngopharynx
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5
Q

describe the nose

A

Air enters the respiratory system

  • Through nostrils or external nares
  • Into nasal vestibule

Nasal hairs

  • Are in nasal vestibule
  • Are the first particle filtration system
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6
Q

describe the nasal cavity

A

The nasal septum
- Divides nasal cavity into left and right

Superior portion of nasal cavity is the olfactory region
- Provides sense of smell

Mucous secretions from paranasal sinus and tears
- Clean and moisten the nasal cavity

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7
Q

name the three types of cartilages in the larynx

A

Thyroid cartilage
Cricoid cartilage
Epiglottis

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8
Q

describe thyroid cartilage

A

forms anterior and lateral walls of larynx

the laryngeal prominence is the Adam’s apple

ligaments attach to thyroid cartilage and hyoid bone

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9
Q

describe cricoid cartilage

A

hyaline cartilage

forms posterior of larynx

articulates with arytenoid cartilage

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10
Q

describe the epiglottis

A

composed of elastic cartilage

folds back over the glottis

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11
Q

describe the larynx

A

Thyroid and cricoid cartilages support and protect:

  • The glottis
  • The entrance to trachea

During swallowing:

  • The larynx is elevated
  • The epiglottis folds back over glottis
  • Prevents entry of food and liquids into respiratory tract
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12
Q

describe the nasopharynx

A

Superior portion of pharynx

Contains pharyngeal tonsils and openings to left and right auditory tubes

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13
Q

describe the oropharynx

A

Middle portion of pharynx

Communicates with oral cavity

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14
Q

describe the laryngopharynx

A

Inferior portion of pharynx

Extends from hyoid bone to entrance of larynx and esophagus

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15
Q

what’s the difference between the glottis and epiglottis?

A

the glottis is used in sound production, as air passes through and vibrates the vocal cords

the epiglottis is the “guardian of the airways” and forms a lid over the larynx when we swallow. This closes off the respiratory passageways to incoming food and drink

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16
Q

what are the incomplete rings of cartilage in the larynx

A

tracheal cartilage, allow for expansion of the esophagus

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17
Q

what are vestibular folds? how are they arranged? how does the larynx function as the human voicebox? what else influences final sound production?

A

upper false vocal cords

lower true vocal cords

vibrate with expelled air for speech

(vocal cords are attached to the arytenoid cartilages by vocal ligaments)

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18
Q

what are the characteristics of lungs

A

in the left and right pleural cavities

inferior portion rests on the diaphragm

lobes are separated by fissures

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19
Q

what are fissures?

A

fissures separate the lobes of the lungs

right lung has three lobes and two fissures (superior, middle, inferior)

left lung has two lobes and one fissure (superior, inferior)

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20
Q

which lung is wider and which is longer?

A

right lung is wider

left lung is longer

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21
Q

what are the components of the respiratory bronchial tree starting with the trachea and ending with the alveoli in the pulmonary lobules?

A
trachea
primary bronchus
secondary bronchus
tertiary bronchi
bronchioles
terminal bronchioles
respiratory bronchioles
alveoli in pulmonary lobule
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22
Q

what composes the respiratory and conducting zones?

A

the respiratory zones are: alveolar sacs, alveolar ducts, and respiratory bronchioles

the conducting zones are everything from the nasal cavity to the terminal bronchioles

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23
Q

what is surfactant’s physiological importance?

A

oily secretion

contains phospholipids and proteins

coats alveolar surfaces and reduces surface tension

lack of surfactant = alveolar collapse

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24
Q

external and internal respiration.

A

external:
- all processes involved in exchanging O2 and CO2 with the environment

internal:

  • result of cellular respiration
  • involves the uptake of O2 and production of CO2 within individual cells
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25
Q

distinguish between atmospheric, intrapulmonary (intra-alveolar) and intra-pleural pressure.

A

normal atmospheric pressure:
1 atm = 760 mm Hg

intrapulmonary (intra-alveolar):

  • relative to atmospheric pressure
  • difference between atmospheric pressure is about -1 -> +1 mm Hg
  • max -30 mm Hg to +100 mm Hg

intra-pleural:

  • pressure in space between parietal and visceral pleura
  • below atmospheric pressure throughout respiratory cycle
  • avg. -4 mm Hg
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26
Q

components of air movement?

A

diaphragm:

  • contraction moves air to lungs
  • 75% of air movement

intercostal muscles:
- 25% of air movement

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27
Q

what is Boyle’s Law and what is the relationship to the direction of airflow during pulmonary ventilation?

A

defines relationship between gas pressure and volume

rate of diffusion depends on physical and gas laws

P = 1/V

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28
Q

how does surface tension influence pulmonary ventilation?

A

increased smooth muscle tension affects airway constriction and resistance

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29
Q

how does compliance influence pulmonary ventilation?

A

indicator of expandibility

low compliance requires more force

high compliance requires less force

levels of surfactant affects compliance

30
Q

what is respiratory rate? what’s the avg. value? how is it related to tidal volume?

A

adapts to changing oxygen demands by varying:

  • number of breaths per minute (respiratory rate)
  • volume of air moved per breath (tidal volume)

500mL

amount of air moved per minute
Is calculated by:
respiratory rate * tidal volume

31
Q

what is the Respiratory Minute Volume (VE) ? what’s the avg. value? what’s the formula?

A

measures pulmonary ventilation

amount of air moved per minute
Is calculated by:
respiratory rate * tidal volume

32
Q

[T/F] is respiratory minute volume the same as pulmonary ventilation?

A

yes

respiratory minute volume = pulmonary ventilation

33
Q

what is the difference between respiratory minute volume (pulmonary ventilation) and alveolar ventilation?

A

pulmonary ventilation is the amount of air moved per minute

alveolar ventilation is the amount of air reaching alveoli each minute:
(tidal volume - anatomic dead space) * respiratory rate

34
Q

what is alveolar ventilation?

A

the amount of air reaching alveoli each minute:

(tidal volume - anatomic dead space) * respiratory rate

35
Q

what is Tidal Volume (VT)?

A

amount of air moved in and out of lungs in a single breath

36
Q

what is Inspiratory Reserve Volume (IRV)?

A

volume of a normal inspiration

Inspiratory capacity:
Tidal volume + inspiratory reserve volume

37
Q

what is Expiratory Reserve Volume (ERV)?

A

volume of a normal exhalation

38
Q

what is Residual Volume?

A

maximal exhalation

39
Q

what is Minimal Volume?

A

the minimal volume needed to support the structure of your lung that always stays there no matter how much you exhale

40
Q

what is Inspiratory capacity?

A

Tidal volume + inspiratory reserve volume

41
Q

what is Functional Residual Capacity (FRC)?

A

Expiratory reserve volume + residual volume

42
Q

what is Vital Capacity?

A

Expiratory reserve volume + tidal volume + inspiratory reserve volume

43
Q

what is Total Lung Capacity?

A

vital capacity + residual volume

44
Q

where does filtration occur? what does it do?

A

Forces water and dissolved solutes out of glomerular capillaries into capsular space

Produces protein-free solution (filtrate) similar to blood plasma

45
Q

what is secretion?

A

to put something into filtrate

out of blood

46
Q

what is reabsorption?

A

take from filtrate

put into blood

47
Q

what does the proximal convoluted tubule do?

A

reabsorption of water, ions, and all organic nutrients

48
Q

what does the loop of henle (nephron loop) do?

A

conserves water and forms concentrated urine

49
Q

what does the distal convoluted tubule do?

A

secretion (of ions, acids, drugs, toxins)

reabsorbs water, sodium, calcium

50
Q

what does the collecting duct do? what ions?

A

variable reabsorption of water and reabsorption/secretion of sodium, potassium, hydrogen, and bicarb ions

51
Q

what is cotransport?

A

two substances transported together across a membrane by one protein

52
Q

what is countertransport?

A

one substance across a membrane, coupled with the simultaneous transport of another substance across the same membrane in the opposite direction

53
Q

what do podocytes do?

A

form the filtration slits of the renal glomerulus

cells in the Bowman’s capsule in the kidneys that wrap around the capillaries

the Bowman’s capsule filters blood

54
Q

what is the renal threshold?

A

the plasma concentration at which a specific compound or ion begins to appear in urine

55
Q

what is normal physiological pH?

A

7.35 - 7.45

56
Q

how does the body maintain normal physiological pH?

A

buffers and respiration

57
Q

what is hypoventilation? what is the result?

A

abnormally low respiration rate allows for CO2 buildup in blood and hypercapnia

58
Q

what is hyperventilation? what is the result?

A

excessive ventilation leads to low PCO2 and hypocapnia

59
Q

what is the formula for the carbonic acid-bicarbonate buffer system?

A

CO2 // (CO2 & H2O) // (H2CO3) carb // (HCO3) bicarb // (Na & HCO3) // NaHCO3 sodium bicarb

60
Q

what causes metabolic acidosis?

A

bicarbonate loss

impaired hydrogen excretion at kidneys

61
Q

how do the kidneys lower/increase blood pH

A

Secrete H+ out of blood

reabsorb H+ into blood

62
Q

how does bicarbonate buffer affect our blood

A

bicarb ions interact with H+ in a solution to form H2CO3 carbonate (removing H+/acid from blood)

63
Q

what does an elevated HCO3 bicarbonate concentration result in?

A

metabolic alkalosis

64
Q

what is the formula for bicarbonate?

A

HCO3-

65
Q

what is the formula for carbonate?

A

H2CO3

66
Q

what does atrial natriuretic peptides do?

A

released by heart in response to stretching walls due to increased blood volume or pressure

reduces blood pressure

67
Q

what is metabolic alkalosis?

A

caused by elevates HCO3 [ ]

bicarbs interact with H+ forming H2CO3

reduced H+ causes alkalosis

68
Q

What does the descending and ascending limb of the nephron loop do?

A

descending: reabsorption of water
ascending: reabsorption of sodium and chloride

69
Q

organization of the respiratory membrane

A
  1. Squamous epithelial cells lining the alveolus
  2. Endothelial cells lining an adjacent capillary
  3. Fused basement membranes between the alveolar and endothelial cells
70
Q

blood supply (pulmonary and systemic circulation) and general pressure in lungs

A
right ventricle
pulmonary arteries
capillary beds of lungs
pulmonary veins
left atrium
left ventricle
aorta
capillary beds of body tissues
venae cavae
right atrium
right ventricle