Exam #1 Flashcards
Define anatomy
the bodily structure of organisms
Define physiology
way in which a living organism or bodily part functions
Define anatomy and physiology
the function of body parts and the body as a whole
Describe the levels of organization
#1 Chemical #2 Cellular #3 Tissue #4 Organ #5 System #6 Organism
Define homeostasis
tendency toward a relatively stable equilibrium between interdependent elements
What are the two mechanisms of regulation for homeostasis?
Auto-regulation: automatic response in a cell, tissue, or organ to some environmental change (the body can divert blood (and thus, oxygen) where it is most needed.)
Extrinsic-regulation: responses controlled by nervous and endocrine systems (When you are exercising, your NS
issues commands that increase
the HR so that blood will circulate
faster.)
Define hydrophobic
repel or fail to mix with water
Define hydrophilic
to mix with, dissolve in, or be wetted by water.
Define polar
one end of a molecule positive and one end negative
Define nonpolar
molecule which has no separation of charge, so no positive or negative poles are formed
Define organic
compounds that contain carbon
Define inorganic
compounds that do not contain carbon
Define hydrolysis
H2O enters, breaking a bond (catabolic)
Define dehydration synthesis
dehydrates, produces H2O and forms a bond (anabolic)
Define catabolic
reactions that break down molecules in metabolism
Define anabolic
synthesis of complex molecules
Define hydrocarbon
compound of hydrogen and carbon
Define denaturation
process where proteins and nucleic acids lose their quaternary, tertiary, or secondary structure.
often by external stressors like temp and pH
loss of function
Define somatic cell
any cell of a living organism other than the reproductive cells
Define germ cell
a gamete, haploid
Define ATPase
adenosine triphosphatease
enzyme that catalyzes ATP to ADP
Define active transport
movement of molecules across a cell membrane from low to high concentration (energy used)
Define passive transport
movement of molecules across a cell membrane from high to low (no energy needed)
Define osmosis
passive transport of water
Define facilitated diffusion
passive transport of solutes by carrier proteins
Define simple diffusion
specific molecules passively permeate a membrane
Define tonicity
the state of a solution in respect of osmotic pressure
Define osmolarity
number of solute particles per liter
Define hypertonic
less solvent than solute when compared to another solution
Define hypotonic
more solvent than solute when compared to another solution
Define isotonic
equal solute to solvent between two solutions
Define sodium-potassium pump
active transport
carrier mediated
sodium ions in
potassium ions out
Define endergonoic
stores energy in bonds (anabolic)
Define exergonic
release energy as bonds are broken (catabolic)
Define phosphorylation
adding a phosphate group to ADP to form ATP
Explain oxidative phosphorylation
oxidation of NADH/FADH necessary to phosphorylate ADP resulting in ATP
Cell physiology
process within and between cells
Organ physiology
functions of specific organs
Systematic physiology
functions of an organ system
Pathological physiology
effects of diseases
Define superior
upper
Define inferior
lower
Define anterior
front
Define posterior
back
Define ventral
front
Define dorsal
back
Define medial
center
Define lateral
side
Define proximal
closer to trunk
Define distal
away from trunk
Define superficial
surface
Define Ipsilateral
same side
Define contralateral
other side
Define supine
laying down face up
Define prone
laying down face down
What are the abdominal pelvic quadrants?
right upper
right lower
left upper
left lower
What are the abdominal pelvic regions?
right/left hypochondriac region
epigastric region
(R: liver L: stomach)
right/left lumbar region
umbilical region
(large and small intestine)
right/left inguinal region
hypogastric region
(small intestine, bladder, appendix)
Identify and describe the sectional planes
frontal plane: front to back
sagittal plane: lefty and right
transverse: superior and inferior
Functions of body cavities
protect organs from accidental shock
permits change in size and shape of organs
Serous membranes
have two layers
parietal layer lines cavity (wall)
visceral layer covers organ (around)
Heart serous membrane
visceral pericardium
parietal pericardium
pericardial cavity
Abdominal serous membrane
parietal peritoneum
visceral peritoneum
peritoneal cavity
Lung serous membrane
parietal pleura
visceral pleura
pleural cavity
What divides the ventral body cavity?
diaphragm
What is the mediastinum?
thoracic cavity
upper portion contains blood vessels, trachea, esophagus, and thymus
lower portion contains pericardial cavity (heart)
Major elements of human body
oxygen
carbon
hydrogen
nitrogen
Define compound
two or more different atoms bound together (NaCl)
Define molecule
two or more similar atoms bound together (O2, H2)
What are the types of chemical bonds?
covalent: sharing of electrons equally, non-polar – or unequally, polar
ionic: transfer of valence shell electron (opposite charges attract)
hydrogen
Define ion
atoms with transferred electrons
Define anion
neg. charged ion
Define cation
pos. charged ion
Define adhesion
sticking to a surface
Define coheasion
sticking to itself
What are the four classes of biological molecules?
carbs
proteins
lipids
nucleic acids
What are the classes of lipids?
triglycerides: store energy
phospholipids: component of cell membranes (polar head, non-polar tail)
steroids: hormones and cholesterol
Function of HDLs and LDLs
high and low density lipoproteins transport cholesterol in human beings
Describe proteins
long chains of amino acids
20 types of amino acids
peptide bonds
Four levels of protein structure
primary - linear shape, sequencing of amino acids, peptide bonds
secondary - hydrogen bonds shape amino acids into a helix
tertiary - folding of the helix by hydrogen bonds (functional), coiled globular
quaternary - individual polypeptides are linked to one another by hydrogen bonds, hemoglobial
Function of enzymes
facilitate biochemical reactions
shape of specialized proteins is dependent on temperature, pH, ion concentration, presence of inhibitors
Relationship between pH and [H+]
as [H+] increases, acidity increases (low pH)
as [H+] decreases, alkalinity increases (high pH)
What power is the pH scale to?
10x each number
pH 5 has 10x more H+ than pH 6
Discuss how changes in blood pH can disrupt homeostasis
pH change damage tissue
slight change in pH can be fatal
pH regulated by liver and kidneys
buffers help reduce change in pH
What is DNA and its function?
deoxyribonucleic acid
determines inherited characteristics
directs protein synthesis
controls enzyme production
controls metabolism
What is RNA and its function?
ribonucleic acid
controls intermediate steps in protein synthesis
Difference in nucleic acids between RNA and DNA
T = U
Types of RNA and their function
messenger: carries DNA code to ribosome
transfer: brings amino acids to ribosome
ribosomal: makes up ribosome and synthesizes proteins
Cell theory
cells are the smallest unit that perform all vital physiological functions
What is ECF
extracellular fluid
solution that
Factors influencing diffusion
distance particle has to move
molecule size
temperature
concentration gradient
electrical forces
Define cytoplasm
all material inside the cell and outside the nucleus
Define cytosol
intracellular fluid
nutrients, ions, proteins, waste
Define organelles
structures inside a cell with specific functions
Describe the head of a phospholipid
polar
hydrophilic
lipophobic
Describe the tail of a phospholipid
non-polar
hydrophobic
lipophilic
What are you expected to draw for the plasma membrane?
phospholipid heads/tails
transmembrane protein
peripheral protein
integral protein
ECF
ICF
What’s the function of the cytoskeleton?
to provide shape and structure to a cell
Describe microtubules
made of tubulin protein
attach to centrosome
anchor organelles
Define metabolism
all chemical reactions in an organism
Define energetics
flow of energy and its changes from one form to another
Define cellular metabolism
all chemical reactions within cells
provides energy to maintain homeostasis
What is glycogen?
branches chain of glucose
abundant storage carbohydrate
stored in liver and muscles
What are triglycerides?
abundant storage lipids
fatty acids
What is cellular respiration and what are its stages?
the harvesting of energy from food
- glycolysis
- citric acid cycle
- electron transport chain
What is oxidation?
the loss of electron
What is reduction?
the gain of electron
What are coenzymes?
used in oxidation
NAD+ and FAD+
remove hydrogen atoms from organic substrates
What is NAD+?
electron carrier that accepts hydrogen to become NADH
used in oxidation
What are the phases of carbohydrate metabolism?
energy investment
energy harvest
DESCRIBE WHAT HAPPENS DURING GLYCOLYSIS
first stage of cellular respiration
does not require oxygen
one glucose is split into two pyruvate
uses 2 ATP
produces 4 ATP
produces 2 NADH
What is crenation?
cell loss of water through osmosis
What is hemolysis?
destruction of red blood cells
What is vesicular transport?
moving particles through the membrane in vesicles
What is endocytosis?
phagocytosis: engulfs a solid particle to form an internal vesicle known as a phagosome
pinocytosis: small particles are brought into the cell, forming an invagination
receptor mediated: specific molecules are ingested into the cell
What is exocytosis?
contents of a cell vacuole are released to the exterior through fusion of the vacuole membrane with the cell membrane
What is osmotic pressure?
force that moves water as a result of the solute concentration
What’s the monomer and polymer for carbohydrates?
monomer: monosaccharide
polymer: polysaccaride
What’s the monomer and polymer for lipids?
monomer: fatty acids
polymer: triglyceride
What’s the monomer and polymer for proteins?
monomer: amino acids
polymer: polypeptide
What’s the monomer and polymer for nucleic acid?
monomer: nucleotides
polymer: polynucleotide
What is the net ATP produced in glycolysis?
2
What is the net ATP produced in the CAC
2
What is the first stage of cellular respiration? Where does it take place?
glycolysis, cytosol
what are the two steps in glycolysis?
energy investment
energy harvest
How many NADH are produced in glycolysis?
2
How many FADH2 is produced in glycolysis?
0
What is the final product of glycolysis?
2 pyruvates
What is the second stage of cellular respiration? Where does it take place?
citric acid cycle, mitochondria matrix
What is the intermediate step in cellular respiration? how much ATP is produced?
Acetyl-CoA
0
How many NADH are produced in the intermediate step in cellular respiration?
2
How many FADH is produced in the intermediate step in cellular respiration?
0
How many NADH are produced during the citric acid cycle?
8
How many FADH2 are produced in the citric acid cycle?
2
What is the purpose of NADH and FADH2?
carry electrons
Where are NADH and FADH2 used?
the ETC
electron transport chain
How many ATP are produced for each NADH used in ETC?
3
How many ATP are produced for each FADH2 used in ETC?
2
How many total ATP are produced from all the NADH from one glucose in ETC?
30
How many total ATP are produced from all the FADH2 from one glucose in ETC?
4
Describe the stages of mitosis
interphase: chromatin replicates
prophase: chromosomes form
prometaphase: chromosomes attack to spindle fibers
metaphase: chromosomes align at center
anaphase: chromosomes separate into chromatid
telophase: nucleus regenerates
What is beta-oxidation?
fatty acid molecules are broken down in the mitochondria to generate acetyl-CoA
What is lipolysis?
breakdown of lipids and involves hydrolysis of triglycerides into glycerol and free fatty acids