Final Flashcards
Blood Glucose: Test
Fasted Sample
Blood Glucose: Sources
Intestinal Absorption (except ruminants), hepatic production, kidney production
Blood Glucose: Regulation
Insulin, glucocorticoids, Catecholamines, glucagon, growth hormone
Insulin: Effects
dec. blood glucose - inc. tissue uptake and liver glycogen storage, inhibits liver gluconeogenesis
Glucocorticoids: Effects
Inc. blood glucose - promote hepatic gluconeogenesis, inhibits insulin binding and action
Catecholamines: Effects
inc. blood glucose - inc. hepatic glycogenolysis, inhibit, insulin secretion and action, stimulate glucagon secretion
Glucagon: Effects
Inc. blood glucose - inc. hepatic gluconeogenesis and glycogenolysis, inhibits insulin binding and action
Growth Hormone: Effects
inc. blood glucose - inhibits cellular glucose uptake and insulin action, inc. hepatic gluconeogenesis
Hypoglycemia: Causes
inc. insulin levels (insulinoma, iatrogenic), sepsis, hepatic failure (dec. gluconeogenesis/glycogenolysis)
Hyperglycemia: Causes
glucocorticoids, catecholamines, diabetes melitus, post-prandial, pancreatitis, hormone imbalance, antifreeze toxicity
What is glucosuria?
BG exceeds renal threshold -or- isn’t reabsorbed
Glucosuria: Causes
Diabetes Melitus, renal tubular dz
Hyperglycemia: Tests
Fructosamine, glucose tolerance test
Exocrine Pancreas: Tests
Amylase (not good), Lipase (not good), TLI, PLI
Maldigestion: Causes
Exocrine Pancreatic Insufficiency
Maldigestion: Signs
voluminous, poorly formed stool, wt loss
Malabsorption: Causes
severe, diffuse intestinal dz
Malabsorption: Signs
voluminous, poorly formed, gray feces, wt loss, hypoproteinemia
EPI: Tests
TLI (blood test)
Malabsorption: Tests
Folate, B12
Malabsorption: Folate and B12 dec.
generalized malabsorption (EPI can mimic)
Malabsorption: Folate dec. only
proximal SI defect
Malabsorption: B12 dec. only
distal SI defect
Malabsorption: Folate inc., B12 dec
bacterial overgrowth
Lipids normally present in blood
Triglycerides, cholesterol, lipoproteins
Primary Hyperlipidemia: Cause
inherited disorder (mini schnauzers)
Secondary Hyperlipidemia: Causes
hypothyroidism, diabetes mellitus, hyperadrenocoricism, pancreatitis, hepatic dz, nephrotic syndrome
Primary Hyperlipidemia: results
Chronic => pancreatitis and seizures
Hypothyroidism - Hyperlipidemia: Results
inc. cholesterol => vascular dz => neurologic/cardiac abnormalities
Diabetes Mellitus - Hyperlipidemia: Results
inc. triglycerides, choleterol
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proeinuria, edema/ascites
Hypolipidemia: Causes
Liver failure, maldigestion/absorption, PLE, starvation
Hyponatremia: Causes
Loss of Na - GI, renal, cutaneous, 3rd space;
Shifts - plasma hyperosmolality;
inc. extracellular H2O - edema;
dec intake
Hyponatremia: Results
hypoosmolality, cellular edema
Hypernatremia: Causes
dehydration - dec. intake, inc. loss
Hypochloremia: Causes
dec. Na, hypochloremic metabolic alkalosis (vomiting, pyloric obstruction), sweating in horses
Corrected Cl Formula
corrected = Cl meausred x (Na normal mean/Na meausred)
Hypochloremia: Paradoxical Aciduria
Reabsorbs Na+ to correct dehydration
Reabsorbs HCO3- instead of Cl- (electoneutrality)
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkaleia
Hyperkalemia: Causes
failure of renal excretion, redistribution, inc. intake
Hyperkalemia - dec. Renal excretion: Causes
a/olicuria, urethral obtruction, ruptured UB, hypoadrenocorticism (dec. aldosterone), loop diuretics
Hyperkalemia - Redistribution: Causes
inorganic acidosis, insulin deficiency, severe muscle trauma
Hypokalemia: Causes
dec. intake, loss (GI, Renal, horse sweat), redistribution
Hypokalemia: Results
weakness, neurologic/cardiac abnormalities
Serum Osmolality Formula
Osmolality = 2Na + (BUN/2.8) + (glucose/18)
Osmole Gap Significance
indicates unaccountable osmole (toxin)
High Anion Gap: Causes
Ketones
Lactate
Uremic Acids (phosphates Sulphates)
Ethylene glycol (other toxins)
T4: Effects
inc. metabolic rate, O2 consumption, HR and contractility; stim. erythropoiesis, catabolize muscle and adipose
What are the ideal Thyroid Function Tests for a cat and dog?
Dog - TT4, FT4, TSH
Cat - TT4, FT4
Thyroid Function Test: TT4 Methods
Radioimmunoassay, snap ELISA
Thyroid Function Test: FT4 Methods
equilibrium dialysis, radioimmunoassay
Thyroid Function Test: TSH
immunoradiometric, chemiluminescent, ELISA
Primary Hypothyroidism: Cause
Autoimmune Dz
Hypothyroidism: Signs
wt. gain, cold intolerance, bradycardia, alopecia, poor hair coat
Hypothyroidism: CBC/Chem Results
non-regenerative anemia,
hypercholesterolemia, hypertriglyceridemia
Hypothyroidism: Thyroid Panel Results
dec. TT4
dec. FT4
inc. TSH (dec. if secondary hypothyroidism)
What is Euthyroid Sick Syndrome?
secondary dec. in TT4 in sick patients.
FT4 and TSH are still normal
Hyperthyroidism: Causes
functional adenoma/hyperplasia, adenocarcinoma
Hyperthyroidism: Signs
palpable thyroid slip, tachycardia, polyphagia, hyperacitvity
Hyperthyroidism: CBC/Chem Results
polycythemia, heinz-body formation (non-hemolytic), stress leukogram,
inc. ALT, azotemia (may be masked
Hyperthyroidism: Thyroid Panel Results
inc. TT4
inc. FT4 (if needed)
PTH: Function
inc. plasma Ca, dec. plasma P
PTH: Effects
bone reabsorption, renal reabsorption, calcitriol (vit D) formation, inc. Ca absorption in GI, inc. P secretion in urine
Hyperparathyroidism: Cause
parathyroid adenoma
Hyperparathyroidism: Chem Results
hypercalcemia, hypophosphotemia, inc. PTH
Hypoparathyroidism: Causes
lymphocytic parathyroidoisis, iatroghenic (thyroidectomy)
Hypoparathyroidism: Chem Results
hypocalcemia, hypophosphotemia, low PTH
ADH: Effects
inc. renal reabsorption of water
Diabetes Insipidus: Types
central (dec. ADH), nephrogenic (dec. response to ADH)
Diabetes Insipidus: Signs
PU/PD, hyposthenuria
Diabetes Insipidus: Differential Tests
ADH response, water deprivation, modified water deprivation
ADH Response Test: Method
administer desmopressin (ADH mimic), monitor SG
ADH Response Test: Results
if urine concentrates => CDI
if urine doesn’t concentrate => NDI
Water Deprivation Test: Method
dehydrate the animal
Water Deprivation Test: Result
If urine concentrates => psychogenic PD
If urine doesn’t concentrate => DI
Adrenal Gland Zones (shallow-deep)
glomerulosa, fasciculata, reticularis
Cortisol: Effect
fat redistribution, protein catabolism, gluconeogenesis, insulin antagonism, anti-inflammatory, immunosuppressive
Hyperadrenocorticism: Causes
Pituitary adenoma (PPDH), functional adrenal tumor (AT), iatrogenic
Hyperadrenocorticism: PPDH Appearance
inc. ACTH, bilateral adrenal hypertrophy
Hyperadrenocorticism: AT Appearance
unilateral adrenal tumor, opposite adrenal atrophy, dec. ACTH
Hyperadrenocorticism: Iatrogenic Apperance
dec. ACTH, bilateral adrenal atrophy
Hyperadrenocorticism: Signs
PU/PD, pot-bellied, muscle weakness, bilateral symmetrical alopecia, calcinosis cutis
Hyperadrenocorticism: CBC/Chem Results
stress leukogram
inc. ALP, ALT, cholesterol
dec. BUN
Hyperadrenocorticism: Diagnostic Tests
LDDS Test, ACTH stimulation Test
Hyperadrenocorticism: Differentiating Tests
LDDS test, HDDS test, endogenous ACTH measurements, imaging
Hyperadrenocorticism: Screening Tests
ALP activity, Urine cortisol: creatinine ratio
L/HDDS Test: Results
If 8hr sample is DEC. => normal
If 8hr sample is INC. => HAC
If 4hr sample is INC. => non-differential
If 4hr sample is DEC. => PPDH
ACTH Stim: Results
if inc. => HAC
if normal => normal
if flatline => iactrogenic
Hypoadrenocorticism: Causes
Primary - Immune mediated destruction
Secondary - destructive lesion
Hypoadrenocorticism: Signs
anorexia, lethargy, vomiting
Hypoadrenocorticism: CBC/Chem Results
non-regenerative anemia, lack of stress leukogram
pre-renal azotemia, inc. BUN, hypoglycemia, Hyponatremia, hyperkalemia
Hypoadrenocorticism: Diagnostic Test
ACTH stim
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperkalemia - dec. Renal excretion: Causes
a/oligouria, urethral obstruction, ruptured UB, hypoadrenocorticism (dec. aldosterone), loop diuretics
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperkalemia - dec. Renal excretion: Causes
a/oligouria, urethral obstruction, ruptured UB, hypoadrenocorticism (dec. aldosterone), loop diuretics
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperkalemia - dec. Renal excretion: Causes
a/oligouria, urethral obstruction, ruptured UB, hypoadrenocorticism (dec. aldosterone), loop diuretics
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperkalemia - dec. Renal excretion: Causes
a/oligouria, urethral obstruction, ruptured UB, hypoadrenocorticism (dec. aldosterone), loop diuretics
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperkalemia - dec. Renal excretion: Causes
a/oligouria, urethral obstruction, ruptured UB, hypoadrenocorticism (dec. aldosterone), loop diuretics
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperkalemia - dec. Renal excretion: Causes
a/oligouria, urethral obstruction, ruptured UB, hypoadrenocorticism (dec. aldosterone), loop diuretics
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperkalemia - dec. Renal excretion: Causes
a/oligouria, urethral obstruction, ruptured UB, hypoadrenocorticism (dec. aldosterone), loop diuretics
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proeinuria, edema/ascites
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkaleia
Hyperkalemia - dec. Renal excretion: Causes
a/olicuria, urethral obtruction, ruptured UB, hypoadrenocorticism (dec. aldosterone), loop diuretics
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperkalemia - dec. Renal excretion: Causes
a/oligouria, urethral obstruction, ruptured UB, hypoadrenocorticism (dec. aldosterone), loop diuretics
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperkalemia - dec. Renal excretion: Causes
a/oligouria, urethral obstruction, ruptured UB, hypoadrenocorticism (dec. aldosterone), loop diuretics
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperkalemia - dec. Renal excretion: Causes
a/oligouria, urethral obstruction, ruptured UB, hypoadrenocorticism (dec. aldosterone), loop diuretics
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperkalemia - dec. Renal excretion: Causes
a/oligouria, urethral obstruction, ruptured UB, hypoadrenocorticism (dec. aldosterone), loop diuretics
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperkalemia - dec. Renal excretion: Causes
a/oligouria, urethral obstruction, ruptured UB, hypoadrenocorticism (dec. aldosterone), loop diuretics
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperkalemia - dec. Renal excretion: Causes
a/oligouria, urethral obstruction, ruptured UB, hypoadrenocorticism (dec. aldosterone), loop diuretics
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Nephrotic Syndrome - Hyperlipidemia: Results
hypercholesterolemia, hypoalbuminemia, proteinuria, edema/ascites
Hyperchloremia: Causes
inc. Na, hyperchloremic metabolic acidosis (GI bicarb loss), alkalemia