Final Flashcards
What are the four functions of the cardiovascular system
deliver oxygen
deliver nutrients
remove waste
regulate temperature
What are the major cardiovascular adjustements to exercise
cardiac output
blood flow distribution
Is the cardiovascualr system closed
yep it just goes from arteries to veins
Which side of the heart is the pulmonary circut
right
what is the left side of the heart a part of
systemic circut
What are the three layers of the myocardium
epi, myo, and endocardium
In what ways is the myocardium similar to skeletal muscle
striated tissue, and the contractile process
What are some unique aspects of the myocardium
short, branched fibers
intercalated disc connections
Atrial/ventricular separation
highly aerobic fibers with large numbers of mithochondria
What are the two phases of the cardiac cycle
Systole and Diastole
What dictates the flow of blood through the heart
pressure (it causes the opening and closing of the valves of the heart
What percent of the passive filling of the ventricles is due to pressure changes
70%
What happens to the phases of the cardiac cycle with exercise
they change
systole is larger in exercise than diastole
diastole is larger in rest than systole
What happens to heart rate with increased exercise
it goes up a lot
What are the values for normal blood pressure
120/80
what are the values for high blood pressure
140/90
What are the factors that influence arterial blood pressure
increase in blood volume increase in heart rate increase in stroke volume increase in blood viscocity increase in peripheral resistance
What are the portions of the electrocariogram and what do they represent
P wave - Depolarization of the atria
QRS - Depolarization of the ventricles
T wave - Repolarization of the ventricles
How does the electrical conduction of the heart go
- you have special autorythmic cells that don’t need input to work
- Influx of sodium causes depolarization at the SA node int the right atria
- that depolarization of the SA node passes to the AV node then to bundle branches, and the perkinje fibers
What is cardiac output (Q)
the indicator of the hearts performance
what is stroke volume
h
what is heart rate
h
What is venous return
h
what is End Diastolic Volume
h
What factors affect cardiac output
preload
afterload
contractility
heart rate
What is the equation for cardiac output Q
Q = SV x HR
What is a normal cardiac output for someone at rest
5 l/min
what is the cardiac output for someone working out
25 l/min
What regulates heart rate
parasympathetic (-) and sympathetic (+)
What are the nerves of the parasympathetic to the heart
vagus nerves and nodes
what are the nerves of sympathetic to the heart
cardiac accelerator nerves, nodes, and ventricles
What causes the increase in heart rate during exercise
parasympathetic withdrawl and sympathetic output
What are the factors that affect stroke volume
end diastolic volume
average aortic blood pressure
strength of ventricular contration
what affects end diastolic volume
venous return
What is end diastolic volume
the amount of blood in the ventricles at the end of diastole
Preload
how does the average aortic blood pressure affect stroke voluem
the higher the pressure in the system, the harder the heart must pump in order to eject blood
What is another name for the strength of ventricular contraction
contractility
What is preload
end diastolic volume
What is the frank starling law
increased EDV = Increased ventricular stretch = Increased SV
How does preload increase SV
enhances the myosin actin interaction
Enchances Ca and kinetics
What leads to increased venous return
venoconstriction
Muscle pump
respiratory pump
What affects venoconstriction
sympathetic output and smooth muscle contraction
what affects the muscle pump
muscle contraction and compression of the veins
What affects the respiratory pump
increased abdominal pressure (inspiration)
What is afterload
the amount of pressure the heart must pump against (TPR)
What affects afterload or TPR
dialition and constriction of the vessels throughout the body
What does TPR do to pumping time
valves open later and close earlier
What affects contractility
Calcium!!
What are the two things that affect contractility
calcium and EDV
what increases intracellular Ca
sympathetic output to myocardium and circulating epi
What things affect HR
parasymp and symp nerves
what things affect SV
MAP
contraction strength
EDV
What are the physical characteristics of blood
RBC WBC platelets hematocrit viscocity
what are the factors that affect blood flow
pressure gradient
what are the things that affect the circulatory pressure gradient
vessel diameter
blood viscocity
What is poiseuilles equation
It basically says that a small change in vessel diameter leads to a large change in blood flow
What happens to oxygen demand during exercise
it increase
What causes an increase in oxygen delivered during exercise
increased Q
redistribution of blood flow to the muscle
What happens to the blood flow to the body during exercise
blood flow to the muscle increases
blood flow to the gut decreases
Where does blood mostly go during exercise
most of it goes to the muscle, some to the skin as well
absolute vs. relative flow
h
What is the autoregulation of blood flow during exercise
local override of the sympathetic output
local vasodialation
What are activators
metabolic by products that induce blood flow to the tissues
Nitric oxide, adenosine, po2, pco2, pH
Where is the cardiovascular control center located
medulla and pons of the brainstem
What affects the CVC
Higher brain centers chemoreceptors hypothalamus baroreceptors muscle afferents PO2, PCO2
What happens to the CV system during exercise
vasoconstriction
increased HR
increased contractility
What does the hypothalaus regulate
temperature
What do baroreceptors do
regulate pressure
What do chemoreceptors do
sense CO2, pH, O2
what do muscle afferents do
sense thermal, mechanical, and chemical stuff
What are the functions of the lungs
ventilation
respiration
diffusion
What makes up the conducting zone of the lungs
trachea
bronchial tree
terminal bronchioles
What makes up the respiratory zone of the lungs
respiratory bronchioles
alveolar sacs
alveoli
What does the conducting zone do
conducts air into the respiratory zone
himidifies, warms and filters the air
What does the respiratory zone do
exchange of gases between the blood and air
how many alveoli are there
300 million
how big are alveoli if they were laid out
60-80 m^2
What are the muscles of inspiration
sternocleidomastoid scalenes external intercostals internal intercostals diaphragm
What are the muscles of expiration
internal intercostals external abdominal oblique internal abdominal oblique transverse abdominis rectus abdominis
What are the mechanics of inspiration
diaphragm pulls downward, lowering intrapulmonary pressure
What are the mechanics of expiration
diaphragm relaxes, raising intrapulmonary pressure
What determines the resistance to airflow
airway diameter
What is pulmonary ventilation
the amount of air moved in and out of the lungs in one minute
what does pulmonary ventilation depend on
tidal volume and breathing frequency
What is daltons law of partial pressure of gasses
the total pressure of a gas mixture is equal to the sum of the pressure that each gas qould exert independently
What percent of air is oxygen
about 20
what is the total pressure of the air
760 mmHG
what is the partial pressure of oxygen
760 x .2 = 159 mmHG
What happens to the partial pressure of oxygen as you increase in altitude
it goes down
what does a decrease in the partial pressure of uxygen do
decreases the gradient, which leads to less O2 binding to HGB
What happens to PO2 from lungs back to lungs
from 100 - 40
What happens to PCO2 fron lungs back to lungs
from 40 - 46
What is pulmonary diffusion
O2 is uptook, CO2 is removed
Does hemoglobin have a high or low affinity for O2
high
what percent of O2 that is transported is bound to HBG
99%
How does the rest of O2 get transported
dissolved
What happens to HGB+O2 with PO2 changes
the higher the PO2 the higher the affinity, starts out steep and levels off