filovirus (ébola) Flashcards

1
Q

qué virus son de la familia Filovirus?

A

ébola
Marburgvirus

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2
Q

características estructurales del filovirus

A

ssRNA-
envuelto
forma filamentosa

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3
Q

zona endémica del filovirus

A

África: selva

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4
Q

origen del filovirus

A

murciélagos a primates

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5
Q

transmisión del filovirus

A

contacto directo: fluidos y objetos contaminados

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6
Q

dónde se multiplican los filovirus?

A
  • monocitos
  • macrófagos
  • células dendríticas
    tormenta inflamatoria similar a sepsis
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7
Q

qué provoca en el cuerpo el filovirus?

A
  • lesión vascular
  • necrosis tisular de hígado, bazo, ganglios linf y pulmones
  • edema
  • CID
  • shock hipovolémico
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8
Q

PDI del ébola

A

2-21 días

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9
Q

manifestaciones del ébola

A

asintomáticos 18%
prodrómico: flu.like
náusea, vómito, diarrea y exantema
fiebre hemorrágica

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10
Q

mortalidad del ébola

A

50-90%

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11
Q

países endémicos del ébola

A

Congo
Liberia
Sudan
Sierra Leona
Guinea

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12
Q

fiebre de Marburgo

A

lab que trabajaba con monos verdes
brotes en Zimbabwe y Kenia

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13
Q

diagnóstico del ébola

A

BSL-4
ELISA
PCR

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14
Q

tx del ébola

A

de soporte
vacuna: rVSV-ZEBOV

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