Fibrous connective tissue

Question 1

3 types of connective tissue

Answer 1

adult, embryonic, special

Question 2

fibrous connective tissue can be divided into three types…which are?

Answer 2

loose CT, dense regular CT, dense irregular CT

Question 3

embryonic CT has what kind of cells?

Answer 3

pluripotent stem cells

Question 4

what do fibroblasts make?

Answer 4

proteoglycans, collagen, glycoproteins, elastin, reticular fibers (all of these are in ECM)

Question 5

CT cell types?

Answer 5

hematopoietic SCs, adipocytes, chondrocytes, osteocytes, fibroblasts, mesenchymal cells

Question 6

elastin can be found primarily in what places?

Answer 6

walls of arteries, lungs, ligamentum nuchae

3 types of elastin: fibrullin 1, fibrullin 1/2, tropoelastin

Question 7

reticular fibers function, found where?

Answer 7

supportive meshwork found in bone marrow, spleen

Question 8

what type of collagen is common in ECMs?

Answer 8

1

Question 9

what is the ECM of CT?

Answer 9

amorphous ground substance (gelatinous, fills space)

Question 10

what does the amorphous ground substance consist of?

Answer 10

proteoglycans (have sulfates - provide cushioning function), hyaluronan (links proteoglycans), glycoproteins (growth factors like TGF-B, EGF), extracellular proenzymes

Question 11

key characteristics of embryonic CT?

Answer 11

lots of ECM, lots of mesenchymal stem cells (multipotent), referred to as wharton’s jelly in umbilical cord

Question 12

loose connective tissue has what cell types in it?

Answer 12

areolar, adipose, retinacular

Question 13

what is areolar?

Answer 13

some fixed cells (fibroblasts, adipocytes, mesenchymal cells), some wandering (macrophages, mast cells, WBCs, plasma cells)

Question 14

characteristic of dense CT?

Answer 14

lots of collagen (so lots of fibroblasts)

Question 15

dense irregular CT example

Answer 15

dermis

Question 16

dense regular CT example

Answer 16

tendon, ligaments, aponeurosis, dense fascia

Question 17

what does loose areolar CT look like on a histological slide?

Answer 17

ECM looks empty, not strong, won’t resist tension

Question 18

functions of white fat?

Answer 18

energy strorage, insulation, cushioning, hormone secretion

Question 19

what does dense regular CT look like in a histological slide?

Answer 19

wavy, poorly vascularized

Question 20

marfan’s syndrome is due to a weakness if what kind of dense CT?

Answer 20

dense connective tissue bc problem with elastin (mutation in fibrullin-1 gene)

*commonly will see ballooning of aortic arch in marfan’s syndrome pts