Fibrous Connective Tissue Flashcards
What are some of the primary functions of CT?
Structural Framework Protection Supports and interconnects tissues Energy storage Transports fluids, cells, and dissolved chemicals
What is the primary function of collagen?
Resist tension
Fibrous component of CT
Scurvy- what are the mechanisms by which this disease occurs (histologically speaking)?
Collagen cross links cannot form
Tissue is “loose” and falls apart/becomes infected easily
Vitamin C important in cross link formations in collagen
Ehler’s Danlos
Abnormal collagen synthesis
Weak collagen fibers; lots of stretching of tissues
What is Marfan’s Syndrome?
Mutation in fibrilin I gene
Affects ocular, skeletal and cardiac musculature
BAD: Can get mitral valve prolapse and dissecting aneurisms
These folks are generally tall and skinny
What is the difference between white and brown fat?
White fat: Energy storage, cushioning, thermoregulation, secretion of hormones
Brown fat: Thermogenic (more abundant in kids)
Embryonic CT
Multipotent
Lots of mesenchymal stem cells
Not much collagen or reticular fibers
FOUND IN ECM
What is Embryonic CT in the umbilical cord called?
Wharton’s Jelly
Adult Mesencymal Stem Cells
Multipotent: Fibroblasts Muscle cells Osteoblasts Chondroblasts Adipocytes
Functions of Loose CT
Supports and bind other tissues; holds body fluids; defends against infection
Location of Loose CT
Beneath membranous epithelia (lamina propria) and around BVs, muscles, and nerves
Types of Loose CT
Areolar
Adipose
Reticular
Areolar CT; general description and cell types
Type of Loose CT
Low density tissue with fixed and wandering cells; widespread
Fixed Cells:
Fibroblasts
Adipocytes
Mesenchymal Cells
Wandering Cells: Macrophages Mast Cells Leukocytes/Lymphocytes Plasma Cells
Adipose Tissue; description, functions, and location
Type of Loose CT
Lots of adipocytes
Sparse ECM
Functions: Supports and protects organs Under skin, around organs (kidney, eyeballs) w/in abdomen, breast and buttocks Energy reserve Protects against heat loss
Reticular CT: Description, Function, Location
Type of Loose CT
Lots of reticular fibers (type II collagen)
Chicken wire to hold free cells
Found in liver, bone marrow, lymph nodes, spleen (holds blood cells and immune cells-free cells)
Functions of Dense CT
Resists pulling forces, allow recoil of tissue following stretching
Types of Dense CT
Dense Regular CT
Dense Irregular CT
Elastic CT
Dense Regular CT: Description, Function, Location
Type of Dense CT
Tightly packed, regularly arranged collagen fibers
Fibroblasts are principle cell types
Poorly vascularized
Has wavy appearance not under tension
Resists Pulling forces
Location: Tendons, Ligaments, Aponeuroses, Dense Fascia, Joint Capsules
Dense Irregular CT: Description, Function, Location
Type of Dense CT
Tightly packed, interwoven collagen fibers running in random patter
Fibroblasts are principle cell type
Location: Dermis Capsules surrounding internal organs Perichondrium and periosteum Fascia
Elastic CT; Description, Function, Location
Type of Dense CT
Lots of Elastic FIbers
Allows recoil of tissue following stretching
Location:
Blood Vessel Walls
Bronchiole Tubules
Ligamentum Nuchae
Fibroblast
Cell of CT
Produces collagen, elastin, reticular fibers, proteoglycans and glycoproteins in ECM
Macrophage
Differentiate from monocytes
Phagocytosis
Mast Cells
Near CT of blood vessels
Secrete
Histamine-Mediate allergic response
Heparin-anticoagulant
Plasma Cells
Differentiate from B Lymphocytes
Produce antibodies to mediate immunity
