Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Opath 2 Midterms > Fibro-osseous Lesions > Flashcards

Fibro-osseous Lesions Flashcards

1
Q

A diverse group of processes that are characterized by replacement of normal bone by fibrous tissue containing a newly formed mineralized product

A

Fibro-osseous lesions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Fibro-osseous lesions of the jaw: entities most commonly include

A

Ossifying fibroma
Fibrous dysplasia
Cemento osseous dysplasia
Periapical/focal
Florid

Chronic osteomyelitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Composed of a fibrous connective tissue stroma in which new bone is formed, it is classified as one of the benign fibrous-osseous lesions of the jaw

A

Ossifying fibroma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Uncommon lesion that tends to occur during the 3rd and 4th decades of life.

Women > men

A

Ossifying fibroma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Generally a slow growing, asymptomatic and expansile lesion.

May be seen in jaws, anterior cranial fossa, craniofacial bones

A

Ossifying fibroma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

An ossifying fibroma that occus in younger pstient (children)

A

Juvenile ossifying fibroma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Important radiographic features of ossifying fibroma

A

Well-circumscribed

Sharply defined borders

Generally expansile profile

Well-circumscribed radiolucency or mixed radiolucency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Two variants of ossifying fibroma that occur in younger patient

A

Juvenile trabecular ossifying fibroma (JTOF)

Juvenila psammomatoid ossifying fibroma (JPOF)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Ossifying fibroma variant that is characterized by progressive and sometimes rapid growth but rarely painful.

A

Juvenile trabecular ossifying fibroma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

A variant of OF that radiographically, shows a defined border and can range from radiodense to radiolucent.

A

Juvenile trabecular ossifying fibroma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

A variant if OF that microscopically, has a high cellular and contains trabeculae or spheroids of new bone

A

Juvenile trabecular ossifying fibroma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Extragnathic craniofacial bone location of juvenile psammomatoid ossifying fibroma

A

Paranasal sinuses
Periorbital bones

Where it can cause exophthalmos, proptosis, sinusitis and nasal symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Juvenile psammomatoid ossifying fibroma occurs principally in ___ craniofacial bones

A

Extragnathic cranofacial bones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

A variant form of OF that microscopically, is formed by cellular stroma containing small, rounded calcifications.

A

Juvenile psammomatoid ossifying fibroma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Treatment for ossifying fibroma

A

Surgical excision or curretage

Resection if shows an aggressive behavior

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Dd of ossifying fibroma

A

Fibrous dysplasia
Osteoblastoma
- younger age, pain
- osteoblasts (++)
- central nidus

Periapical cemento osseous dysplasia
- (+) posterior teeth
- needs biospy confirmation

Focal osteomyelitis
- inflammation and pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Ossifying fibroma is clinically, microscopically identical to ?

A

Cementifying fibroma aka cemento ossifying fibroma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Composed of fibrous connective tissue with well-differentiated, spindled fibroblasts.

A

Ossifying fibroma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Bone is immature and often surrounded by osteoblasts.

Osteoclasts are infrequently seen

A

Ossifying fibroma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Why does ossifying fibroma and fibrous dysplasia a primary diagnostic challenge in distinguishing them both?

A

They may exhibit similar clinical, radiographic and microscopic features.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

The most helpful feature in distinguishing fibrous dysplasia and ossifying fibrous is?

A

OF is well-circumscribed. Well-defined appearance is evident.

And the ease with which it can be separated from normal bone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What gene does fibrous dysplasia have but ossifying fibroma doesn’t have?

A

GNAS 1a gene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Most commonly presents as an asymptomatic, slow enlargement of single/several bone

A

Fibrous dysplasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Fibrous dysplasia that is used to describe the process in one bone

A

Monostotic fibrous dysplasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Fibrous dysplasia that applies to cases in which more than one bone is involved.
Polyostotic fibrous dysplasia
26
Which is more common. Polyostotic or monostotic fibrous dysplasia?
Monostotic fibrous dysplasia (80%) of cases
27
When fibrous dysplasia maxillary lesion that may extend to involve the maxillary sinus, zygoma, sphenoid bone and floor of the orbit. This is now referred to as?
Craniofacial fibrous dysplasia
28
Maxilla > mandible for fibrous dysplasia. But, if lesion is in mandible, the most common occurrence is where?
Body of the mandible
29
Onset of fibrous dysplasia
First or second decade of life
30
Gender predisposition of mono and poly fibrous dysplasia
Monostotic = gender prediection Polystotic = more common in female
31
Radiographic appearance of fibrous dysplasia
Radiopaque that imparts a “ground glass” or “peau d’orange” effect
32
How many radiographic patterns is fibrous dysplasia have?
Radiolucent to radiopaque mass 1. Ground glass effect 2. Unilocular or multilocular radiolucency - in long bones 3. Mottled radiolucent and radiopaque appearance - long standing disease
33
Aside ffrom ground glass effect seen in radiographic features of fibrous dysplasia. What are the other radiograph features to support that the lesion is a fibrous dysplasia?
Fingerprint bone pattern Superior displacement of the mandibular canal in mandibular lesions
34
An important distinguishing feature of fibrous dysplasia
Poorly defined radiographic and clinical margins of the lesion
35
Normal medullary bone is replaced by an abnormal fibrous connective tissue proliferation in which new, nonmaturing bone is formed
Fibrous dysplasia
36
Lab findings in fibrous dysplasia for monostotic and polyostotic
Mono = Serum calcium, phosporus, alkaline phosphatase are normal Polyostotic (McCune-Albright syndrome) = altered
37
DD of fibrous dysplasia
Ossifying fibroma Chronic osteomyelitis - inflammation, tenderness, pain Malignancy (osteosarcoma)
38
Treatment for fibrous dysplasia
Though growth, it stabilizes Surgical recontouring for large lesions that causes functional deformity RANKL medications - to improve pain and bone density
39
A type of fibrous dysplasia that can cause malignant transformation, though less than 1% of cases
Polyostotic type of fibrous dysplasia
40
% of regrowth in fibrous dysplasia
25%
41
Unusual response of Periapical bone and cementum to some undetermined local afactori
Periapical cemento-osseous dysplasia
42
3 types of cemento osseous dysplasia
Periapical COD Focal COD Florid COD
43
Characterized by the replacement of normal bone with a collagenous matrix containing trabecular of immature bone and in some instances, cementum-like material
Cemento osseous dysplasia
44
Uncommon primary lesion of bone that arises in maxilla or mandible It is a benign neoplasmof undetermined cause
Osteoblastoma
45
A lesions that Clinically and histologically, they may be confused with osteosarcoma
Osteoblastoma
46
CM in diameter for osteoblastoma and steoid osteoma
Osteoblastoma = larger than 1.5cm in diameter Osteoid osteoma = 1.5cm or less
47
Common location of osteoblastoma
Most often in vertebrae and long bones Less in jaws
48
Common location of osteoblastoma if located in the jaw
Posterior tooth bearing regions of maxilla and mandible
49
Age for osteoblastoma
Second decade 90% appears before age of 30
50
Gender predilection of osteoblastoma
2:1 Male , female
51
Radiographic feature of osteoblastoma
Well circumscribed and have a lytic to mixed lucent-opaque pattern
52
A constant feature of osteoid osteoma that may be absent in osteoblastoma
Sclerosis of perilesional bone
53
Composed of irregular trabecular of osteoid and immature bone within a stroma containing a prominent vascular network
Osteoblastoma
54
DD of osteoblastoma
Cementoblastoma Ossifying fibroma Fibrous dysplasia Osteosarcoma
55
Treatment for osteoblastoma
Conservative surgical approach (curettage or local excision)
56
Associated with gardner’s syndrome Consists of mature, compact, or cancellous bone.
Osteoma
57
Osteoma that arise on the surface are called ___ Osteoma that develop centraly within bone ___
Periosteal osteoma Endosteal or solitary central osteoma
58
Age and gender predilection of osteoma
2nd to 5th decade of life Male > female
59
An osteoma that clinically presents as asymptomatic, slow-growing, bony, hard masses.
Periosteal osteoma
60
An osteoma that occurs within the medullary bone and may be discovered during routine radiographic exam as dense, well-circumscribed radiopacities
Endosteal osteomas
61
70% of cases located within the mandible
Osteoma
62
Symtpoms associated with these tumor . Headaches, recurrent sinusitis, ophthalmologic complains
Osteomas
63
Inherited as an autosomal-dominant disorder, is characterized by intestinal polyposis, multiple osteomas, fibromas of the skin, epidermal and trichilemmal cysts, impacted permanet and supernumerary teeth and odontomas
Gardner syndrome
64
Genetic defect is gardner syndrome is found in?
Small region on the long arm of chromosome 5 (5q21) Where the familial adenomatous polyposis (APC) gene resides
65
Intestinal polyps associated with gardner syndrome are commonly located in the __ and __
Colon and rectum
66
Two distinct histologic variant of osteoma
1. Composed of relatively dense, compact bone with SPARSE marrow tissue. 2. Lamellar trabecular of cancellous bone with ABUNDANT fibrosis-fatty marrow
67
Osteoblasts may be numerous, but osteoclasts are sparse
Osteoma
68
DD of osteoma
Exostosis Osteoblastoma/osteoid osteoma Odontoma, cemenoblastoma, condensing osteitis, focal sclerosing osteomyelitis
69
Developmental 1. Single/multiple bone 2. Max > mndi 3. Slow, painless swelling 4. Polyostotic; syndromes (mccune albright syndrome)
Fibrous dysplasia
70
Most common: tooth bearing areas 1. Mid-aged female, asymptomatic
Cemento osseous dysplasia
71
Neoplasm 1. 20-30 years old: female 2. Mandi < max 3. Small: asymptomatic 4. Large: painless swelling
Ossifying fibroma
72
Mode of ossification of bone
Intramembranous ossification
73
Darker purple stain indicates?
Immature bone or woven bone
74
In this lesion, the bone is predominantly woven Bony trabeculae assume irregular shapes likened to chinese characters
Fibrous dysplasia
75
Composed mostly of lamellar bone, compact or trabecular, in which osteoblasts and osteoclasts are usually inconspicuous
Osteoma

Opath 2 Midterms (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions