Fibrinolytics And Anti Fibrinolytics

Question 1

What is the function of Fibrinolytics

Answer 1

Lyse thrombi rapidly by promoting conversion of plasminogen to plasmin. Plasmin degrades fibrin and rapidly dissolves in the blood clot

Question 2

Name plasminogen activators/ Fibrinolytics

Answer 2

1. Streptokinase
2. urokinase
3. alteplase 
4. Reteplase
5. Tenecteplase

Question 3

What are the adverse effects of Fibrinolytics 

Answer 3

1. Bleeding, hypotension
2. allergic reactions
3. fever, chills, skin rashes
4. anaphylactoid reaction

Question 4

What are the uses of Fibrinolytics

Answer 4

1. Acute myocardial infarction
2. deep vein thrombosis
3. pulmonary embolism

Question 5

What are the contraindications of Fibrinolytics

Answer 5

1. Recent trauma, recent surgery, recent abortion
2. Recent stroke
3. severe hypertension
4. severe diabetes
5. Severe liver damage
6. peptic ulcer
7. bleeding disorders

Question 6

What is the mechanism of anti-Fibrinolytics 

Answer 6

They block the conversion of plasminogen to plasmin and inhibit Fibrinolytic activity

Question 7

Name Anti-fibrinolytic drugs

Answer 7

1. Epsilon-amino caproic acid
2. tranexamic acid

Question 8

What are the uses of epsilon amino caproic acid

Answer 8

1. Overdose on fibrinolytics
2. after tooth extraction
3. prostate surgery in haemophiliacs

Question 9

What are the uses of tranexamic acid

Answer 9

1. menorrhagia
2. excessive Fibrinolytic activity
3. tonsillectomy
4. prostatectomy
5. tooth extraction