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Pharmacology Blood > Antiplatelet Drugs > Flashcards

Antiplatelet Drugs Flashcards

1
Q

Classify antiplatelet drug’s

A
  1. Thromboxane synthesis inhibitors
  2. phosphodiesterase inhibitors
  3. purinergic receptor antagonist
  4. glycoprotein IIb/IIIa Receptor antagonist
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2
Q

Name thromboxane synthesis inhibitor’s

A

Low-dose aspirin

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3
Q

Name a phosphodiester inhibitor

A

Dipyrimadole

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4
Q

Name purinergic receptor antagonist

A
  1. Ticlopidine
  2. Clopidogrel
  3. Prasugrel
  4. Cangrelor
  5. Ticagrelor 
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5
Q

Name glycoprotein IIb/IIIa receptor antagonist

A
  1. Abciximab 
  2. Eptifibatide
  3. Tirofiban
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6
Q

What is the mechanism of action of aspirin

A

Irreversibly Acetylates platelet COX-1 and reduces the production of TXA2.

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7
Q

Why is aspirin at higher levels not as effective

A

Because it inhibits both TXA2 and PGI2

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8
Q

What is the mechanism of action of dipyrimadole 

A

Vasodilator. It inhibits phosphodiesterase and increases the concentration of cyclic AMP

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9
Q

What is the mechanism of action of purinergic receptor antagonist

A

The inhibit ADP mediated playing the aggregation by irreversibly blocking purinergic receptors on platelets

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10
Q

Which drugs produce a synergistic effect with purinergic receptor antagonist

A
  1. Aspirin
  2. glycoprotein IIb/ IIIa antagonists
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11
Q

What are the adverse effects of purinergic receptor antagonist

A
  1. Diarrhoea
  2. thrombocytopenia
  3. neutropenia
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12
Q

What is the mechanism of action of glycoprotein receptor antagonist

A
  1. Block glycoprotein receptors IIb/IIIa for fibrinogen and von Willibrands factor on platelet surface
  2. inhibit the final step in the process of platelet aggregation produced by platelet agonists
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13
Q

What are the uses Glycoprotein receptor antagonist

A
  1. Percutaneous coronary intervention
  2. unstable angina
  3. acute myocardial infarction
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14
Q

What Are the uses of anti-platelet drugs

A
  1. Acute coronary syndrome (Acute myocardial infarction, angina)
  2. Coronary artery disease
  3. prosthetic heart valve
  4. transit ischaemic attack
  5. peripheral artery disease
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15
Q

What should we give into a patient with non-ST elevation myocardial infarction

A

Dual antiplatelet therapy. Aspirin With purinergic receptor antagonist for at least a year

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16
Q

What should be given to a patient with ST elevation myocardial infarction

A
  1. Aspirin and purinergic Receptorantagonist you’re diagnosis.
  2. After, purinergic receptor blockers or thrombolytics should be used
17
Q

Which drugs can be used in combination to prevent thromboembolism Or valve thrombosis

A
  1. Aspirin and warfarin
  2. Warfarin and dipyridamole 
18
Q

What can be used for secondary prevention of TIA transit ischaemic attack

A
  1. Aspirin
  2. clopidogrel
  3. aspirin + dipyridamole

Pharmacology Blood (5 decks)

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