Fibrinolytics

Question 1

What drugs stimulate fibrinolysis?

Answer 1

Convert Plasminogen to plasmin:
- Streptokinase
- Recombinant human tPA
* Reteplase
* Altepase
* Tenecteplase
- Urokinase

Question 2

What is streptokinase?

Answer 2

• From streptococci
• Cleared by the liver
• Antigenic antibodies form after 4 days
• Can’t use for 1 year after dose is given

Question 3

What is altepase?

Answer 3

• Decreases mortality in MI
• Treatment of acute ischemic stroke, DVT&PE
• More active on fibrin - bound plasminogen than plasma plasminogen
• Has to be given within 6-12hrs, idealy within 1hr

Question 4

What is Tenectplase?

Answer 4

• Decreases in MI
• More active on fibrin - bound plasminogen than plasma plasminogen.
• Reteplase given within 12hrs, idealy <1hr
• Tenecteplase given within 6hrs, idealy <1hr