FIBRATES

Question 1

Fibrates MOA

Answer 1

increase catabolism of VLDL particles
decrease TG

Question 2

Fenofibrate

Answer 2

Antara
Tricor
Trillpix
Fenoglide
Fibrcor
Lipofen
Triglide

Question 3

Antara dosing

Answer 3

30-90mg QD

Question 4

Fenofibrate dosing

Answer 4

43-130mg QD

Question 5

Fenoglide dosing

Answer 5

40-120mg QD w/meals

Question 6

Fibricor dosing

Answer 6

35-105mg QD

Question 7

Lipofen dosing

Answer 7

50-150mg QD w/meals

Question 8

TriCor dosing

Answer 8

48-145mg QD

Question 9

Triglide dosing

Answer 9

160mg QD

Question 10

Triliprix dosing

Answer 10

45-135mg QD

Question 11

Contraindicaton

Answer 11

severe liver disease
gallbladder disease
breastfeeding (derivative only}
repaglinide or simvastatin (gemfibrozil)

Question 12

Warnings fenofibrate

Answer 12

increased risk of myopathy with statin (particually elderly, DM, renal failure or hypothyroidism)

Question 13

Side Effects of fibrates

Answer 13

dyspepsia (gemfibrozil)
increased LFT

Question 14

What should not be given with ezetimibe or statin

Answer 14

gemfibrozil (increased risk of myopathy)

Question 15

What affect which class of medication

Answer 15

sulfonylureas
warfarin

Question 16

Lipid Effects fibrates

Answer 16

decreased TG
can increase LDL when TG are high