Fever DSA Flashcards
Range for fever Dx
Above 100.9 F or 37.8 C
Night sweats are caused by…
Exaggeration of normal circadian temperature rhythm
What molecules are responsible for fever? Where do they act? What does it produce?
Endogenous pyrogens act at the hypothalamus and lead to an increase in local PGE2, monoamines, Na+, Ca++, etc.
3 endogenous pyrogens causing fever
IL-1
TNF
INF-alpha
What is different between TNF and IL-1?
TNF does NOT activate WBCs
Hyperthermia definition
An elevation in body temperature due to loss of homeostatic mechanisms and inability to increase heat loss in response to environmental heat, as in heat stroke.
Fever of unknown origin (FUO)
Fever lasting 3 wks or more with temps exceeding 38.3 C (100.9 F) with no Dx despite 1 wk of clinical investigation
Most common cause of fever in older patients…
Infection in RT, UT with skin and soft tissue
4 common causes of fever
Infection
AI dz
CNS dz
Malignancy
Drug fever definition
Fever coinciding w/ administration of a drug and disappearing after d/c of the drug, when no other cause for the fever is evident after careful exam/workup
Best tools for determining body temp (2)
Greatest variability is with what tool?
Electronic and infrared thermometers
Tympanic thermometer
In patients with fever, the best predictors of bacteremia are the patient’s…
Underlying diseases (renal failure, trauma, etc.)
Presence of shaking in a pt. w/ fever increases the probability of…
Bacteremia
Most common infectious causes of FUO (2)
Tb
Intra-abdominal abscesses
Most common malignancies causing FUO (2)
Hodgkin’s or non-Hodgkin’s lymphoma