Female Triad Flashcards

1
Q

What are the 3 points of the triad

A

Low energy/disordered eating

Bone loss/osteoporosis

Menstrual disturbances/amenorrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which female athletes are at risk of developing the triad?

A

Athletes participating in sports that emphasize low body weight or subjective judging of appearance

gymnasts, figure skaters, ballet, diving, dancing, wrestling, long distance running’s judo, talk won do

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

In addition to the pressure to maintain a low weight, why else do these sports increase risk for th triad

A

They are not team sports and are socially isolating, as a result of extreme focus on training

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Why are the corners of the triad related to each other?

A
  1. PRESSURE to perform at optimal levels and a perceived requirement to maintain low body mass
  2. Results in lots of training and LOW food intake
  3. This plus psychological stress Leads to physiological disturbance in the endocrine control of the menstrual cycle
  4. This causes increased risk in developing amenorrhea
  5. This leads to decreased production of ovarian estrogen
  6. This leads to decreased bone mineral density/ risk of low BMD and osteoporosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How does the triad get activated?

A

Athlete belief that low weight enhances performance + EMOTIONAL STRESSORS= begins to “diet”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What happens after the woman begins to “diet”?

A

Diet becomes increasingly restrictive and training becomes excessive —> caloric restriction —-> menstrual dysfunction and decreased bone mineral density

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are some ~emotional stressors~ that can trigger the initiation of the triad?

A

Death of a coach/family member

Growth spurt

Illness that prevents training

Moving to university

Pressure/difficult standards

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the happy triad?

A

Optimal energy intake, optimal bone health, eumenorrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What’s the big deal with not eating enough

A

Body switches from reproduction/growth to SURVIVAL.

Reduced ATP for cell function, thermoregulation, growth and reproduction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Do most of the athletes in the triad have clinical mental disorders like anorexia or bulimia

A

NO!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the 2 mechanisms to explain the low energy availability?

A
  1. Exhibiting behaviors such as not taking in enough food to offset exercise, food restriction, laxatives, diuretics, enemas, binging and purging
  2. Clinical mental disorders- anorexia and bulimia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How does decreased energy intake lead to decreased estrogen production?

A

After 5 days of energy availability being reduced from 45 down to 30 kcal/kg FFM/day, the PULSATILITY of GnRH and LH/FSH release is disrupted

This leads to decreased E2 production, accelerating bone resorption and decreased bone mineral density

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the NORMAL energy availability?

A

45 kcal/kg/FFM/day**

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What happens to LH pulse profiles when EA drops to 30, 20, and 10?

A

30- amplitudes decrease

20 and 10- frequency low, amplitude way up

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the threshold EA when things start to go wrong?

A

30 kcal/kg/FFM/day

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Reducing energy intake is associated with _______ LH amplitude and _______ pulse frequency

A

Increased amplitude

Decreased frequency

17
Q

What effect will low EA have on ketone and 2*Glucose

A

Ketone body formation up

2* glucose down

18
Q

What effect will low EA have on cortisol and insulin?

A

Cortisol up- BONE RESORPTION**, decreased peripheral glucose uptake, gluconeogensis

Insulin down

19
Q

What effect will low EA have on Growth hormone and IGF

A

GH up

IGF down

(GH goes up for metabolic effects, NOT for growth)

20
Q

What effect will low EA have on thyroid hormone and leptin

A

Both decreased

21
Q

What is the process from eumenorrhea to amenorrhea

A

Eumenorrhea —> luteal phase deficiency —> anovulatoin —> oligomenorrhea —> amenorrhea

22
Q

What is a luteal phase defect?

A

Menstrual cycle with a luteal phase less than 10 days or low progesterone

Follicular phase is prolonged, but cycle length doesn’t change

Athlete will ovulate and menstruate

23
Q

What is anovulation

A

Menstrual cycle without ovulation

Low estrogen and progesterone

Impaired follicular development

Athlete will often menstruate (cycles can be shortened or prolonged)

24
Q

What is oligomenorrhea

A

35 days or more between cycles

Irregular menses

25
Q

What is amenorrhea

A

Amenorrhea occurring after menarche

Absence of mesntrual cycle for more than 90 days

26
Q

What happens to the length of the luteal phase in LPD

A

Shortened

27
Q

What happens to the level of progesterone in anovulatory runners

A

Almost none

28
Q

What kind of scanner shows you the density of your bones

A

DEXA Scan

Dual Energy X-ray absorptiometry

29
Q

What are the 2 scores that BMD is based on?

A

T score- used in America

Z score

30
Q

What is a T score?

A

BMD compared to a young normal reference mean. US standards use data for a healthy 30-year old of the same sex and ethnicity as the patient

31
Q

What T score indicates:
Osteoporosis

Low bone mass

Normal

A

Osteoporosis: less than -2.5

Low bone mass: -1 to -2.5

Normal: -1 or higher

32
Q

What is a Z-score?

A

Comparison of the patients BMD to an age matched population and considering the patient’s sex and ethnicity

33
Q

Is a 75 year old Asian woman’s T-score based on someone her age and ethnicity?

A

No it will be based on a healthy 30 year old Asian woman

34
Q

Who is a 50 year old black woman’s Z-score based on

A

Another 50 year old black woman

35
Q

Who has the lowest T-scores:
Amenorrhea

Oligomenorrhea

Eumenorrhea

A

Amenorrhea

36
Q

Is the female triad ONLY A NUTRITONAL ISSUE

A

YES!!!****

37
Q

What is the pathophysoilogical basics of the triad

A

A NUTRITIONAL ISSUE

38
Q

Is the triad a MENTAL disorder

A

NO!!! They ONLY way to treat is to fix the diet