Female Reproductive System Flashcards

1
Q

The follicles that are formed during fetal life are called ____________.

A

Primordial follicles

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2
Q

Primordial Follicle consists of a (primary oocyte/oogonium) ___________ enveloped by a single layer of the flattened follicular cells.

A

Primary oocyte

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3
Q

_____________ occur in the superficial

ovarian cortex.

A

Primordial follicles

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4
Q

Beginning in the (second/third) _______ month, oogonia begin to enter the prophase of the first meiotic division but arrest after completing synapsis and recombination.

A

Third monthh

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5
Q

The cells arrested in meiosis 1 are called (Primary oocytes/oogonia) _________.

A

Primary oocytes

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6
Q

At puberty the ovaries contain about __________ oocytes.

A

300,000

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7
Q
By the (7th/8th) \_\_\_\_\_\_\_ month of development, most
oogonia have transformed into primary oocytes within follicles.
A

7th

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8
Q

In developing ovaries of a 2-month embryo, there

are about ________ oogonia that produce more than 7 million by the fifth month.

A

600,000

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9
Q

Many primary oocytes, however, are lost through a

slow, continuous degenerative process called _________.

A

Atresia

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10
Q

The oocyte in the primordial follicle is spherical and about (25/120) ____ μm in diameter.

A

25 μm

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11
Q

Growth of oocyte is prompted by ______ hormone.

A

FSH

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12
Q

Specialized secretory granules called ___________ are formed in oocyte containing various proteases due to FSH.

A

Cortical granules

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13
Q

_____________ lie just inside the oocyte’s plasma membrane and undergo exocytosis early in fertilization.

A

Cortical granules

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14
Q

Follicular cells undergo mitosis and form a simple cuboidal epithelium around the growing oocyte. This follicle is called ___________

A

Unilaminar Primary Follicle

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15
Q

The follicular cells continue to proliferate, forming

a stratified follicular epithelium called _________.

A

Granulosa

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16
Q

The follicle with stratified epithelium is known as ___________.

A

Multilaminar Primary Follicle

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17
Q

Between the oocyte and the first layer of granulosa cells of the growing primary follicle, extracellular material accumulates as the ____________.

A

Zona Pellucida

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18
Q

The zona pellucida components (ZP1 and ZP2/ZP3 and ZP4) ________ are important sperm receptors binding specific proteins on the sperm surface and inducing acrosomal activation.

A

ZP3 and ZP4

19
Q

__________ of granulosa cells and __________ of the oocyte penetrate the zona pellucida, allowing communication between these cells via gap junctions.

A

Filopodia of granulosa cells

Microvilli of the oocyte

20
Q

Growing primary follicles can become involved in (disease) __________.

A

Polycystic ovary syndrome

21
Q

The etiology of PCOS is increased ___________ production by the ovaries or adrenals.

22
Q

Stromal cells outside the follicle give rise to ___________.

A

Thecal cells (theca interna and theca externa)

23
Q

Theca ________ is vascularized endocrine tissue.

24
Q

Theca _________ is fibromuscular in nature (having fibroblasts and smooth muscles)

25
Theca interna produces __________ that diffuses into the follicle's basement membrane and is converted to estrogen by granulosa cells.
androstenedione
26
Androstenedione is converted to estrogen by the enzyme __________, which is FSH dependent.
Aromatase
27
``` As the (primary follicles/secondary follicles) __________ grow, they move deeper in the ovarian cortex. ```
primary follicles
28
The granulosa cells secrete a fluid that coalesce and the granulosa cells reorganize themselves to form a fluid filled cavity called __________
Antrum
29
Follicles having an antrum are termed as (primary follicles/secondary follicles) _____________.
Secondary follicles
30
Those granulosa cells that immediately surround the zona pellucida make up the (cumulus oophorus/corona radiata) ____________
corona radiata
31
As the antrum develops, the granulosa cells around the | oocyte form a small hillock, (cumulus oophorus/corona radiata) ____________, which protrudes into the antrum
cumulus oophorus
32
The multiple layers of granulosa cells are collectivelly called _____________
Stratum granulosum
33
The theca interna consists mainly (cuboidal/columnar) __________ cells.
Cuboidal
34
Theca ________ has smooth muscles that contract to release ovum.
Externa
35
A multilaminar primary follicle is also known as ___________ follicle.
Preantral follicle`
36
Liqour folliculi is an exudate of ________.
Plasma
37
The granulosa layer becomes thinner at this stage because its cells do not multiply in proportion to the growth of the antrum. This is the feature of (secondary/graffian) __________ follicle.
graffian follicle
38
The theca interna cells appear __________ and lightly stained because of their cytoplasmic lipid droplets, a characteristic of steroid-producing cells.
vacuolated
39
Follicles at (any stage/primary/secondary) ___________ of development may become atretic
any stage
40
Follicular cysts are common and usually benign, but can produce high (estrogen/progesterone) _________ levels and lead to menstrual irregularities.
estrogen
41
If cyst formation disrupts blood vessels blood enters the fluid, often rapidly, and produces a __________ cyst.
hemorrhagic cyst
42
Ovulation normally occurs at ________.
Day 14
43
Before ovulation, the mature follicle bulging against the tunica albuginea develops a whitish ischemic area, the _____________
Stigma