Development of Female Reproductive System Flashcards
Gonad differentiation starts due to the arrival of _____________ in the posterior abdominal wall.
Primordial Germ cells
The gonads are not differentiated until week __ (5/6/7)
week 6
The primordial germ cells arrise from the _________ and then they migrate to the wall of the yolk sac in third week.
epiblast
They migrate to the wall of the yolk sac close to the ________ in third week through primitive streak
allantois
During the (5th/6th) ____ week of gestation, the primordial germ cells migrate along the dorsal mesentery of hind gut to reach the posterior abdominal wall.
5th week
Primordial germ cells stimulate coelomic epithelium to thicken forming a pair of longitudinal ridges on both sides called ____________
Genital Ridges
The genital ridges are located ventromedial to the _____________
mesonepric kidneys
During the 6th week of gestation, the PGCs stimulate the surface epitelium to form ______________.
Primitive Sex cords
The _____________ surround the PGCs
primitive sex cords
Due to the formation of primitive sex cords, the gonad has now an outer ________ and an inner ___________.
Cortex/ Medulla
The primitive sex cords degenrate into rete ovarii due to the absence of __________ in females
Y chromosome
Ovarian development begins in ________ week, while the testes start developing in 7th week.
12th week
The primordial germ cells differentiate into primary oocytes and these oocyte stimulate surface epithelium to give rise to ___________.
Cortical sex cords
The cortical sex cords continue to proliferate and split into clusters of cells called _____________.
Follicular cells
These follicular cells or pregranulosa cells surround the oocyte at week ______, forming primordial follicle.
16
The surface epithelium of the ovary gets separated from the primordial follicles by a connective tissue covering called _____________.
Tunica Albuginea
The surface epithelium becomes (flat/columnar) ___________ and is continuous with the peritoneum/mesovarium.
flat
At _______ week of gestation, male and female embryos begin with two pair of ducts called
- Paramesonephric ducts (female)
- Mesonephric ducts (male)
6th
The mesonephric ducts degenerate because there are no ___________ in females.
sertoli/ leydig cells that make testosterone
The paramesonephric ducts are formed from the longitudinal invaginations of ______________.
surface epithelium
the paramesonephric ducts are (medial/lateral) _________ to the mesonephric ducts.
lateral
the paramesonephric duct develop from (cranio-caudal/caudo-cranial) ______________ side.
Craniocaudal
The caudal ends of the paramesonephric ducts fuse to form ______________.
Uterovaginal primordium
The cranial end of the paramesonephric duct form _____________ opening in the abdominal cavity
Indundibulum of the uterine tubes
The middle horizontal part of the paramesonephric duct crosses (ventral/dorsal) ____________ to the mesonephric duct.
ventral
The developing paramesonephric duct remains uninhibited due to the absense of ________ (hormone)
Antimullerian hormone or Mullerian inhibiting substance
_________ (hormone) stimulates the development of the paramesonephric duct.
Estrogen (from placenta and mother)
The uterovaginal primordium gives rise to the _________ and ______________
uterus and vagina
After fusion of the paramesonephric duct, a broad transverse pelvic fold is established called ___________.
Broad ligament of the uterus
the broad ligament forms the _____________ pouch anterior to the uterus and a _____________ pouch posterior to the uterus.
Vesicouterine pouch
Rectouterine pouch
Alongsides of the uterus, between the layers of broad ligament, mesenchyme proliferates to form _____________.
Parametrium
The fused paramesonephric duct is surrounded by mesenchyme that will give rise to ____________ and _____________
Myometrium and endometrial stroma
The perimetrium is continuous with the _____________ on the body of uterus
broad ligament
Parametrium is composed of _____________ and (dense/loose) ________ connective tissue
smooth muscles and loose connective tissue
The uterovaginal primordium projects into the posterior wall of the urogenital sinus forming a ___________ in the wall of sinus.
Sinus tubercle
Solid evaginations grow out from the pelvic part of the sinus called _____________ that will give rise to vaginal plate.
sinovaginal bulb
The vaginal plate canalizes at ________ month
fifth
The fibromuscular wall of vagina is derived from the ______________.
mesenchyme
The lumen of the vagina is separated by ____________ from the cavity of urogenital sinus.
hymen
Hymen is made by the invagination of the posterior wall of the urogenital sinus, resulting from the expansion of __________.
vaginal plate
Outgrowths from urogenital sinus form ____________ glands in lower third of labia majora.
Greater vestibular glands
Outgrowths from the urethra into mesenchyme form bilateral mucus secreting __________ and ______________ glands
urethral and paraurethral glands
