Female Reproductive Anatomy and Physiology Flashcards
What does the vulva refer to?
refers to all these external structures Vaginal orifice influenced by childbirth, exposing anterior vaginal wall
- What artery supplies the the pelvic arterial flow?
- And what artery branches from this?
- Aorta-common iliac—external and internal iliac
- Uterine artery as branch of internal iliac or hypogastric
What form the fallopian tubes and then fuse caudally to form uterus, cervix and upper vagina? 2
- Mullerian or
- paramesonephric ducts
- What is a gartner’s duct cyst?
- What are the sites for this? 3
- A Gartner’s duct cyst (sometimes incorrectly referred to as vaginal inclusion cyst) is a benign vaginal cystic lesion that arises from the vestigial remnant of a mesonephric duct or Gartner’s duct.
2.
- epoophoron
- Cervix
- Vagina
DES (Diethylstilbesterol)
- Later associated with uterine anomalies which caused what? 2
- Exposed sons have increased risk of what? 3
- Mothers have modest increase risk of what?
1.
- increased pregnancy complications and infertility as well as
- increased risk of cervical and breast cancer
2.
- cryptorchidism,
- hypogonadism and
- epidiymal cysts
3. breast cancer
- DES associated with what of vagina in DES exposed daughters in 1971 and use stopped in US?
Use continued in some other countries until early 1980’s. (Youngest exposed in US about 44 yo now.) Increase also in uterine anomalies (Tshaped uterus, hypoplastic uterus and uterine adhesions created increase infertility, ectopic preg and early preg loss. These daughters need yearly exams with cervical and 4 quadrant vaginal pap as well as careful vaginal palpation to screen for clear cell carcinoma. Mothers who took DES have mild-moderate increase risk of breast cancer (17%). Third generation effects equivocal.
- clear cell carcinoma
What do the following pelvic types describe:
- Gynecoid?
- Platypelloid?
- Android?
- Anthropoid?
- Round
- Oval
- Wedge
- Oval-long
Ovulation requires a what?
surge of prostaglandin synthesis within the follicle
- Hypothalamus loctaed where?
- Hypothalamic-Hypophyseal Portal Circulation is the blood supply where?
- Located at base of brain, just above junction of optic nerves
- The blood supply of anterior pituitary originates in the hypothalamus
There are no direct nerve connections
State what the following are:
- GnRH?
- TRH?
- SRIF?
- CRF?
- PIF?
- – gonadotropin-releasing hormone
- – thyrotropin-releasing hormone
- – somatotropin release-inhibiting factor (somatostatin or growth hormone inhibiting-hormone)
- – corticotropin-releasing factor
- – prolactin release-inhibiting factor = dopamine
Anterior pituitary (Adenohypohysis)
- Derived from what?
- Produces how many different hormones?
Posterior pituitary (Neurohypophysis)
- Derived from what?
- Transports what? 2
Anterior pituitary (Adenohypohysis)
- Derived from ectoderm
- Different cell types that produce 6 different hormones
Posterior pituitary (Neurohypophysis)
- Derived from neural tissue
- Transports oxytocin and vasopressin
Anterior Pituitary- Adenohypophysis
What are the 6 hormones that are released by this?
- FSH – follicle stimulating hormone – gonadotrophs
- LH – luteinizing hormone – gonadotrophs
- TSH – thyroid stimulating hormone – thyrotrophs
- Prolactin – lactotrophs
- GH – growth hormone
- ACTH – adenocorticotrophic hormone – MSH (melanocyte stimulating hormone – Addison’s disease)
- Which hormones are released by Hypothalamic Neurohormone? 5
- GnRH
- TRH
- SRIF
- CRF
- PIF (Dopamine)
What do the following signal for the anterior pit to release?
- GnRH?
- TRH?
- SRIF?
- CRF?
- PIF (Dopamine)?
1.
- FSH
- LH
2. TSH
3. GH
4.
- ACTH
- MSH
5. Prolactin
What are the target organs for the following hormones?
- FSH and LH?
- TSH?
- GH?
- ACTH and MSH?
- Prolactin?
- Ovaries
- Thyroid
- Skeletal system
- Adrenals
- Breasts
Pulsatile secretion of GnRH from the (arcuate nucleus) hypothalamus
- Stimulated by what?
- Inhibited by what?
- Influenced by what?
- Low pulse frequency triggers what?
- High pulse frequency triggers what?
- Stimulated by norepinephrine
- Inhibited by dopamine (PIF)
- Influenced by endogenous opiods
- Low pulse frequency triggers FSH
- High pulse frequency triggers LH
Hypothalamic-Pituitary-Ovarian Axis
- GnRH reaches the anterior pituitary by what?
- and stimulates secretion of what?
- hypothalamic-pituitary portal vascular system
- FSH (follicle stimulating hormone) and LH (luteinizing hormone)
LH
- First, low levels stimulate what and from where?
- These androgens are converted to ________ in the granulosa cells
FSH
- Stimulates secretion of what 2 from what?
- secretion of androgens (testosterone and androstenedione) from the theca cells.
- ESTROGENS
- ESTROGENS (estradiol and estrone) by granulosa cells of ovarian follicles
Estrogen and LH: Ovulation
- Initially, estrogen creates a negative feedback to the pituitary to__________ LH and FSH?
- In late follicular phase, peak estradiol levels from the dominant follicle trigger what?
- decrease
- a midcycle surge of LH needed for ovulation and preparing the ovary to make progesterone
Progesterone
- With ovulation, the dominant follicle becomes a progesterone-secreting cyst called the what?
- and the ________ of menstrual cycle begins.
- corpus luteum
- luteal phase
Progesterone:
- Negative feedback on pituitary secretion of LH and FSH causes what?
- decreasing E and P to be made in corpus luteum
Progesterone
- If no conception, the lifespan of the corpus luteum is ____days.
- Progesterone levels ____?
- _______ period triggered
- Negative feedback for FSH secretion stops and FSH levels start to do what?
- 9-11
- fall
- Menstrual
- to rise before onset of menses
Progesterone:
If implantation occurs:
What from the zygote sustains the corpus luteum for 6-7 weeks until the placenta takes over?
HCG (human chorionic gonadotropin)