Female Hyperandrogenism Flashcards
Excess growth of male-pattern, pigmented terminal hairs on body midline
Hirsutism
Markers of androgen production in these origins
Ovary
Adrenal gland
Peripheral conversion
Testosterone
DHEA-S
3a-diol-G
Excess male pattern hair Inc muscle mass Clitoromegaly Temporal balding Deepening of voice
Virilization
Excess of nonsexual hair
Hypertrichosis
Hyperamdrogenism
Inc free androgen
Inc 5 reductase
Inc free androgen
Ovary
Adrenal gland
Ovarian production of androgen
Gradual onset
Infertility anovulation obesity
Inc DHT
PCOS
OCP
Ovarian production of androgen
Rapid
Unilateral pelvic mass with virilization
Inc DHT
Androgen producing tumors like Sertoli Leydig cell
Surgical removal
Adrenal production of androgens
Most common
Androgen producing tumors
Adrenal production of androgens
Premature pubarche acne accelerated bone age menstrual irregularity
Elevated 17OHP
Late onset CAH
Glucocorticoid
Adrenal production of androgens
Inc ACTH
Inc glucocorticoid and androgen
Cushing’s disease
Surgical
Inc 5a reductase enzyme
N testosterone DHEAS 17OHP
Mediterranean
Hair follicle androgen sensitivity
Spironolactone