Female Breast Anatomy Flashcards
At what gestational age do mammary glands begin to develop?
6W LMP
Mammary ridges AKA
Milk Lines
Which ducts have already developed by birth?
main lactiferous ducts
When do breasts ripen? (age)
9-16 years
What hormone stimulates TDLU growth?
progesterone
Rapid breast growth at puberty is AKA
thelarche
What is premature thelarche?
early breast development (6-8 years)
Breasts are not completely mature until
pregnancy and lactation occur
When are breasts mature if no immediate pregnancy after menarche?
2 years after menarche
Which breast is typically larger?
left
Congenital breast anomalies (6)
- nipple inversion
- athelia
- polythelia
- amastia
- polymastia
- amazia
Nipple inversion, when congenital, is typically
bilateral
Athelia AKA
absence of nipple
Absence of nipple AKA
Athelia
What is the #1 congenital breast anomaly?
Polythelia (Accessory Nipples)
Polythelia AKA
Accessory Nipples, #1 most common, typically inferior to normal nipple
Amastia
Failure of breast tissue and nipple to develop
Polymastia
Accessory breast tissue, usually with no nipple
Polymastia is more common in
men, typically axillary
Amazia
Absence of functioning breast tissue, under a normal nipple
Breasts AKA
Mammary Glands
Layers of tissue seen sonographically: (6)
- Skin
- Premammary layer
- Mammary layer
- Retromammary layer
- Muscle layer
- Chest wall
How thick is the breast skin layer?
0.5-2mm thick, most thick at base
What is the nipple composed of?
erectile tissues, and 15-20 excretory ducts for milk
The areola is made of
smooth muscle tissue
Montgomery Glands:
sebaceous glands on areolar surface that secrete protective oils during lactation
Axillary Tail of Spence:
mammary tissue that extends into upper outer quadrant and axilla region
Where does the pectoralis muscle lie?
2nd-6th rib, sternum-axilla
Where does the breast lie?
inferior to 1st or 2nd rib, superior to 7th
What is the most common palpable finding mistaken for a mass?
rib
Which nerves innervate each breast?
right and left intercostal
Premammary Layer AKA
Subcutaneous Fat Layer
The premammary layer is present everywhere but
posterior to nipple
What can be found in the premammary layer?
sebaceous cysts and lipomas
The fat found in the premammary layer can vary depending on:
age, obesity, pregnancy
Two other names for Mammary layer:
Glandular or Parenchymal
Where does most breast pathology occur?
Mammary Layer
What tissues comprise the Glandular layer ?
Epithelial and Stromal
Epithelial Tissues:
FUNCTIONAL: TDLU, lobules, lactiferous ducts
Stromal Tissues:
STRUCTURAL: fat and connective tissues
Each breast has how many lobes?
15-20, arranged in radial fashion around nipple
Smallest functional unit?
acini cells, produce milk, found inside lobules
Interlobular CT AKA
Coopers Ligaments
Intralobular CT:
less dense than Coopers Ligaments, surrounds each individual lobule of breast tissue
Which part of the breast contains the most glandular tissue?
upper outer quadrant
How many acini cells per breast?
100’s
What makes up TDLU?
30-50 acinar cells grouped together in a lobule with associated terminal ducts
How large are typical TDLUs?
<2mm
TDLU size in pts with fibrocystic disease or adenosis:
up to 5 mm
TDLU proliferation occurs when?
reproductive years and pregnancy/lactation
TDLU atrophy occurs when?
cessation of breast feeding and postmenopausal
Where in the breast are most TDLUs found?
anterior, most pathology arises in superficial half of mammary zone
Non-lactating ducts measure:
<2mm
Lactating ducts measure:
<8mm
Describe milk flow through breast:
Acini Cells in Lobules>Intralobular Ducts>Extralobular Ducts>Interlobular Ducts>Main Terminal Duct>Lactiferous Sinus/Ampulla>Collection/Excretory Ducts>Nipple
Internal Thoracic Artery AKA
Internal Mammary Artery- supplies medial breast, originates at subclavian art
Which artery supplies the lateral breast?
Lateral Thoracic Artery
How does lymph drainage move in the breast?
deep>superficial (towards areola)>then towards axilla
1 site for lymph node mets from breast CA?
Axillary
Level 1 Axillary Lymph Node Classification:
found in nodes lateral to pectoralis minor
-pectoral, subscapular, lateral, paramammary
Level 2 Axillary Lymph Node Classification:
Deep to pectoralis minor
-interpectoral and central nodes
Level 3 Axillary Lymph Node Classification:
found in nodes medial to pectoralis minor
-apical
Which accessory nodes are considered distant for mets, and therefore have a poor prognosis?
supraclavicular
T/F: Normal mammary nodes have posterior enhancement.
False, they do not have posterior enhancement
What hormone stimulates ductal proliferation?
estrogen
What hormone stimulates lobular proliferation?
progesterone (causes PMS symptoms in breast)
Which organ /gland excretes prolactin inhibitors?
hypothalamus
Which organ/gland excretes prolactin?
pituitary
Which organ/gland excretes oxytocin?
pituitary
What does oxytocin do?
causes ductal contraction to expel milk
Carcinoembryonic Antigen (CEA) is secreted by which organ?
the liver - levels assessed after diagnosis, should decrease with tumor removal
What role does Alkaline Phosphatase play in lab work for breast cancer?
ezyme levels used to rule out tumor mets in patients with known cancer..elevated in some liver, bone, lung, and pancreatic cancers
The classification used for supernumerary breast tissue
Kajava’s Classification