Feline Mast Cell Tumors Etc

Question 1

Which feline MCT is more commonly seen?

Answer 1

Mastocytic form

Question 2

Which feline MCT is often seen in young Siamese cats and what are the features?

Answer 2

Histiocytic form

Marked eosinophilic and lymphoid infiltrate present Can spontaneously regress

Question 3

Where are histocytic mast cell tumors usually found?

Answer 3

Head and neck

Question 4

History and CS of Mastocytic and compact

Answer 4

-Solitary, raised, firm, well circumscribed, dermal nodule 
• 20 - 25% of cats have multiple MCT’s 
• Head and neck most common 
• Pinnae, near the base of the ear 
• Patients with multiple compact MCT’s
typically have less than 5 tumors

Question 5

Is histologic grading prognostic?

Answer 5

Yes, >1 cutaneous lesions NOT correlated with degree of malignancy or probability of metastasis

Majority (80%) of solitary cutaneous MCTs behave in a benign fashion

Question 6

What’s the difference on cytology between cat and dog MCT?

Answer 6

Granules are more Eosinophilic than dog mast cells

Question 7

Tx and Prognosis of feline MCT

Answer 7

Conservative sx mgt in 80%
Chemo not indicated if operable solitary skin tumor

Px good in most cases

Will use systemic therapy for non resectable tumors

Chemo -> minimal data available, CCNU, vinblastine, toceranib and pred

Question 8

What are diffuse miliary MCTs?

Answer 8

-Multiple mast cell tumors distributed
throughout the skin 
• Uncommon 
• Patients often have 10’s to > 100 mast
cell tumors within the skin

Question 9

How to to diffuse miliary cutaneous MCTs

Answer 9

Chemo

Symptomatic tx’s: H1 and H2 blockers

Question 10

Feline MCT splenic age, does it metastasize?

Answer 10

More common than in dogs
• Older cats, median age 10 yr
• Metastatic potential

Question 11

Hx and CS of splenic MCT

Answer 11

Depression, anorexia, weight loss
• Hepatomegaly, splenomegaly
• Peritoneal/pleural effusions
• Anemia, circulating mast cells

Question 12

Tx and Px for Splenic MCT

Answer 12

Splenectomy 
Prognostic factors –
– LN metastasis, needing transfusion 
• Not prognostic for shorter survival
– bone marrow or liver status 
• Expectations for Survival:
– Surgery alone 12-19 mos 
• Chemotherapy is recommended following Sx

Question 13

Tx for intestinal MCTs?

Answer 13

Resection and anastamosis

Question 14

What are soft tissue sarcomas?

Answer 14

Heterogenous group of cancers with similar path features and biologic behavior

Question 15

Are soft tissue sarcomas hemangiosarcomas, histiocytic sarc, OSA

Answer 15

No!

Question 16

Where do soft tissue sarcomas arise from?

Answer 16

Embryonic mesoderm

Question 17

Where can soft tissue sarcomas occur?

Answer 17

Anywhere in the body

Question 18

CS for STS depend on______

Answer 18

Location in the body

Question 19

Task Force recommendations for feline associated sarcoma and vx strategies to help

Answer 19

Consider malignant if >2cm, nodule present 3 mo after vx, increasing in size >4 wks

Intradermal vx, giving the vx distal in the limb, decrease vx frequency, asses patient risk -> don’t vx if they don’t need it

Question 20

Most common sites of metastasis for STS?

Answer 20

Lungs (most common)
Liver and or spleen
LN

Question 21

T/F No marginal resection for vaccine associated sarcomas

Answer 21

True

Question 22

When removing a vx assc STS remove at least _____cm margins

Answer 22

2cm

3-5cm best

Question 23

OSA in dogs

Answer 23

#1 primary bone tumor 
85% of skeletal malignancies 
Middle age and older dogs
Large and giant breed dogs

Question 24

Where is most OSA tumors located

Answer 24

Appendicular skeleton, metaphyseal areas
Towards the knee away from the elbow
Thoracic limbs are affected twice as often as pelvic limbs

Question 25

50% of axial OSA occur in ____ and ______

Answer 25

Mandible and maxilla