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SAM II > Chemo And Systemic Therapy > Flashcards

Chemo And Systemic Therapy Flashcards

1
Q

T/F Surgery cures more cancer each year than radiation or chemo/systemic therapy

A

True

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2
Q

What is the Goldie Coldman Hypothesis?

A

Once the tumors has reached 1 million cells, it is likely that chemo resistant cells have developed due to mutations

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3
Q

What is Gompertezian Growth?

A

Tumor growth rate isn’t constant, it grows exponentially early on then slows down.
Chemo is most effective during rapid growth

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4
Q

What does BAG stand for

A

Chemo side effects
Bone marrow
Alopecia
GI

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5
Q

How low do WBCs have to be to start giving prophylactic antibiotics?

A
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6
Q

In what patients do we want to avoid doxorubicin in?

A

Dobie w/ cardiomyopathy

Geriatric cat with CRF

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7
Q

T/F Checking calculation of drug doses is crucial because even a decimal point in the wrong direction can be 10x the dose and fatal

A

True

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8
Q

3 ways you can prevent aerosolization

A

Closed system
Phaseal system
Equashield

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9
Q

T/F Chemo tablets and capsules have to split and open in order to work properly

A

FALSE
That shit will aerosolize and contaminate the environment
No liquid/oral formulations either

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10
Q

What drugs are Alkylating agents?

A 
Cyclophosphamide
Chlorambucil 
Melphalan 
CCNU 
Ifosfamide
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11
Q

Mechanism of Action for Alkylating Agents

A

Alkylate DNA bases
Cross links
Induce apoptosis

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12
Q

Alkylating agent toxicity

A

BAG
Cyclophosphamide- acrolein (inactive part of the drug) causes steril hemorrhagic cytitis)
CCNU- hepat

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13
Q

What drugs are anti metabolites?

A

5-FU, cytosine arabinoside, methotrexate, gemcitabine

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14
Q

MOA and Tox for anti metabolites

A

-MOA: interrupt DNA synthesis, methorexate inhibits dihydrofolate reductase, reduced folate
required for nucleotide synthesis
-Tox; 5-FU NOT used in cats, BAG in dogs

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15
Q

What drugs are vincristine and vinblastine?

A

Spindle toxins

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16
Q

MOA of spindle toxins

A

bind tubulin/interfere w/ mitotic spindle, Vinca alkaloids inhibit spindle formation and
Taxanes inhibit microtubule disassembly

17
Q

Tox of spindle toxins?

A

Vincristine causes BAG, minimal myelosuppression, GI toxicity due to ileus
(common), peripheral neuropathy, tissue irritation w/ extravasation
Vinblastine causes BAG Taxanes cause allergic reactions

18
Q

What drugs are anti tumor antibiotics

A

Doxorubicin, mitoxantrone, epirubicin

19
Q

MOA of anti tumor antibiotics

A

intercalation into DNA, inhibition of topoisomerase II, production of free radicals, cell
membrane damate

20
Q

What drug causes “red death” aka irreversible cardiotoxicity in cats

A

Doxorubricin

21
Q

What are the platinum drugs and what’s their MOA

A

Cisplatnum, carboplatnum

MOA: cross link DNA

22
Q

What drug causes fatal indiosyncratic pulmonary edema in cats

A

Cisplastin

23
Q

Cisplastin stimulates the ____ causing vomiting almost immediately

A

CRTZ

24
Q

How does L-asparaginase work?

A

Cleaves asparagine which is required by lymphoma and other hematopoietic tumors

25
Q

T/F L-asparaginase causes BAG side effects

A

False, it can cause allergic rxns

26
Q

What drugs are anti metabolites?

A

5-FU, cytosine arabinoside, methotrexate, gemcitabine

27
Q

MOA and Tox for anti metabolites

A

-MOA: interrupt DNA synthesis, methorexate inhibits dihydrofolate reductase, reduced folate
required for nucleotide synthesis
-Tox; 5-FU NOT used in cats, BAG in dogs

28
Q

What drugs are vincristine and vinblastine?

A

Spindle toxins

29
Q

MOA of spindle toxins

A

bind tubulin/interfere w/ mitotic spindle, Vinca alkaloids inhibit spindle formation and
Taxanes inhibit microtubule disassembly

30
Q

Tox of spindle toxins?

A

Vincristine causes BAG, minimal myelosuppression, GI toxicity due to ileus
(common), peripheral neuropathy, tissue irritation w/ extravasation
Vinblastine causes BAG Taxanes cause allergic reactions

31
Q

What drugs are anti tumor antibiotics

A

Doxorubicin, mitoxantrone, epirubicin

32
Q

MOA of anti tumor antibiotics

A

intercalation into DNA, inhibition of topoisomerase II, production of free radicals, cell
membrane damate

33
Q

What drug causes “red death” aka irreversible cardiotoxicity in cats

A

Doxorubricin

34
Q

What are the platinum drugs and what’s their MOA

A

Cisplatnum, carboplatnum

MOA: cross link DNA

35
Q

What drug causes fatal indiosyncratic pulmonary edema in cats

A

Cisplastin

36
Q

Cisplastin stimulates the ____ causing vomiting almost immediately

A

CRTZ

37
Q

How does L-asparaginase work?

A

Cleaves asparagine which is required by lymphoma and other hematopoietic tumors

38
Q

T/F L-asparaginase causes BAG side effects

A

False, it can cause allergic rxns

SAM II (9 decks)

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