Feline LRT Disease Flashcards

1
Q

What can be an important clue to diagnosis?

What age range tends to acquire lower airway disease in cats?

A

Age at presentation.

Lower airway disease tends to affect young adult to middle aged cats but can affect cats of any age.

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2
Q

What diseases do older cats increase suspicion for?

A

Hyperthyroidism
Neoplasia
Cardiac disease

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3
Q

What diseases do younger cats and kittens increase suspicion for?

A
Viral
Parasitic
Mycoplasma
Bacterial
Toxoplasma
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4
Q

What is the clinical history of feline LRT disease?

A
Usually a low grade chronic disease. 
Coughing.
Audible wheezing.
“Exercise intolerance”.
Sometimes a very acute presentation...
-brought in as an emergency
-respiratory distress
-mouth breathing
-tachypnoea
Episodic respiratory distress...
-self limiting?
-respiratory effort?

Check for a more chronic history in these cases….have the owners overlooked that the cat is coughing?

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5
Q

What questions should we ask about the patients’ history?

A
Are there any trigger factors?
-change in environment?
-new cat litter?
-passive smoking?
-seasonal?
Is the cough productive?
Is anything “brought up”?
-often confusion with hair balls.
Any significant weight loss, anorexia?
-consider other differentials.
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6
Q

Acute or chronic disease?

A

Cats are excellent at masking their clinical signs…
quieter?
staying in bed all day?
less playful?
grooming less?
staying at floor level/reluctant to jump up on furniture?

An emergency presentation doesn’t always mean an acute disease.

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7
Q

Lower airway disease in the cat - graph.

A

Purple line – sudden deterioration from nowhere, clinical signs, a real sort of spike and continue having problems until effective treatment decided and given,
Other cats – fairly chronic low grade disease, subtle, owners may not be aware of it as very subtle signs,
Other – episodic crisises, sudden onset deterioration.

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8
Q

How to assess the cat and determine how critical the situation is?

A
Respiratory reserve often minimal.
Sympathetic stimulation is counterproductive.
-transport
-waiting room
-is it “cat friendly”?
-physical exam
Initial assessment should be hands off.
Triage emergency patients
- are there trained staff empowered to make decisions?
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9
Q

What should you prioritise?

A

Oxygenation

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10
Q

What should be observed during a physical examination?

A

Respiratory patterns (watch and listen, try to localise disease)

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11
Q

As an example, how could you use respiratory patterns to diagnose upper respiratory disease in cats?

A
Laryngeal disease
- Laboured inspiration...
stridor
↑ effort
slow inspiratory phase
- +/- change in...
purr 
vocalisation
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12
Q

Fleur - cat that had laryngeal lymphoma (picture).

A

Here she has a temporary tracheotomy tube in place after her laryngeal biopsy was taken. It’s worth thinking about why a biopsy procedure might make things worse in a cat with severe respiratory distress associated with a laryngeal mass. She did well once she started chemotherapy for her lymphoma. Her tracheotomy tube was removed the day after she started treatment.

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13
Q

In upper airway disease in cats, what should you check the clinical history for signs of?

A

Dysphagia +/- salivation.
Coughing /gagging.
-might be triggered by eating/drinking
“Head shaking” behaviour.

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14
Q

What can be seen with lower airway disease in cats?

A
- Laboured expiration...
prolonged expiratory phase
additional expiratory push
audible expiratory wheeze
- ↑ airway resistance due to
bronchospasm
mucous
bronchial wall thickening
- +/- occasional paroxysmal cough
owners may think “fur ball”
- does the signalment fit?

Harder to pick up, harder for owners to pick up.
Increased expiratory effort – so lungs fill quite easily but it is hard for the lungs to empty.
Increased airway resistance, increased mucus production as part of an inflammatory response.
Spasm, thickening of the bronchial wall, contributing to narrowing of the airways.

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15
Q

What can be seen on physical examination of a cat with lower airway disease?

A
Can be deceptively normal
- rule out other diseases?
Auscultation:
quiet room
listen for an expiratory wheeze
is the heart normal?
--no murmur
--no gallop rhythm
--no tachycardia
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16
Q

What is feline asthma?

A
A type of airway disease.
Reversible
Inhaled allergen
Airway hyper-reactivity
Bronchoconstriction
Eosinophilic airway inflammation?
Signs: episodic respiratory distress and dyspnoea.

Similar to human asthma in that - a reversible situation, an immune mediated process whereby an inhaled allergen sets off a trigger and you get a reaction in the airways. Signs similar to human asthma.

17
Q

What is chronic bronchitis?

A
A type of airway disease. 
Response to infection or inhaled irritants. 
Airway damage
Excess mucus
Neutrophilic airway inflammation?
Signs: coughing is a key feature. 

Doesn’t have quite the same degree of hypersensitivity but it is similar, more associated with a chronic cough than an inflammatory flare up.

18
Q

Feline asthma and chronic bronchitis…

A

Currently…. without a better understanding of the aetiology of these two conditions, there is a lot of overlap in terms of presentation and treatment is essentially the same.

19
Q

What is the pathogenesis of airway disease? Why do things spiral out of control?

A

Hyper-reactivity of the bronchial smooth muscle…
-type I hypersensitivity
-autonomic imbalance
-mucociliary imbalance
Acute bronchoconstriction in response to a trigger factor.
Inflammation of bronchial mucosal lining…
-histamine and leukotriene release.

Acute bronchoconstriction associated with inflammation – can be quite devastating.

Airway obstruction occurs due to...
-bronchoconstriction 
-inflammation
-mucus in narrowed bronchioles
Air trapping -> destruction of alveoli.
End result is chronic damage
- irreversible situation due to remodelling. 
- may see spontaneous rib fractures. 
Extreme acute deterioration
- rare cases develop pneumothorax.

Air trapping because the lungs can’t empty – these tends to gradually destroy the alveoli. End result of this condition can be irreversible extreme damage – remodelling and fibrotic changes within the alveolar walls.

20
Q

What are the Ddx. for coughing in cats?

A
Upper respiratory tract disease. 
Inflammatory lower airway disease
Infectious – bacterial, viral, parasitic
Foreign body
Neoplasia

Heart disease rarely causes coughing in cats.

21
Q

What are the Ddx. for hyperpnoea/tachypnoea

in cats?

A
Stress/pain/fear response
mouth breathing
- 8/103 cats improved with sedation only. 
CNS disease
Anaemia/hypovolaemia
Heatstroke

Think about non cardiorespiratory causes:
could your patient have been in an RTA?

Cardiac disease
Respiratory disease
-airways
-lung parenchyma
Pleural space disease
Mediastinal disease
Ruptured diaphragm

Very often it is going to be cardiac disease or respiratory disease.
Pleural space important, especially in cats as a range of reasons they get pleural effusion/pleural fluid.

22
Q

What is involved in the diagnostic plan for respiratory disease in cats? (as part of a management plan).

A
Haematology and biochemistry
-what should we look for?
Diagnostic imaging
-radiography?
-ultrasound?
-advanced imaging?
--CT/MRI
Bronchoscopy?
- bronchoalveloar lavage
Endotracheal wash?
Faecal analysis for parasites.

Haematology – idea of whether systemic inflammation from chronic disease going on, anaemia of chronic disease. If increased eosinophils, how high are these? – allergy or hypereosinophilic syndrome in cats?

Is it safe to go ahead with the investigations?
Should we consider a treatment trial especially if
- investigations at this stage are considered too risky?
–some owners are especially risk averse…
- owners cannot afford any diagnostics.

Reaching a diagnosis is a luxury in some cases….
very often we just need to work with what we have.
History and physical exam are so important!

23
Q

What is the management plan when there is suspected airway disease in cats?

A
Rule out other causes of coughing and dyspnoea:
Preoxygenate
GA –but only if stable
Thoracic radiographs:
-might be normal (20% of cats?)
-bronchial pattern
-+/- interstitial
-hyperinflation
-air trapping
-collapse of R middle lung lobe?
-patchy alveolar pattern?
-aerophagia->air in stomach
Bronchoscopy:
-hyperaemia
-oedema
-excess mucus
-↓ airway diameter
Think about the risks:
-aggravating irritable airways
-moving plugs of mucus
-bronchospasm
BAL/blind tracheal wash:
- cytology
interpretation difficult
DDx for eosinophilic inflammation include
viral pneumonia
parasitic
HES
- bacterial culture
- Mycoplasma PCR

Risks of BAL: hyper reactive airways prone to bronchospasm during bronchoscopy and BAL procedures.

HES= hypereosinophilic syndrome.
Smear of some mucus.
Pass some saline through tube (often urinary catheter in cats as useful sized tube) and suck back what you can.

24
Q

Reviewing the history for this 14 year old MN DSH cat who was referred for further investigations: he had lost some weight, was quiet and less keen to eat but not coughing. Physical examination revealed a heart rate of 250 (at rest) and tachypnoea (RR 38). Auscultation revealed a gallop rhythm and a systolic murmur (grade III/VI). We should not have airway disease at the top of the list of differentials for a cat like this.

A

This cat should not have had a BAL…. (however it was carried out):

  • BAL from a cat with CHF
  • Perl’s stain showing positive for iron (haemosiderin) in the macrophages
  • Known as “heart failure cells”
  • Feature of chronic congestion.
25
Q

What is an appropriate management plan in a crisis situation of suspected airway disease?

A
Oxygenate 
Manage inflammation
- dexamethasone iv
Manage bronchospasm
- terbutaline
-> selective β2 receptor agonist 
--smooth muscle relaxant
--bronchodilation
-> ideally rule out heart disease 1st
- inhaled salbutamol
-> selective β2 receptor agonist 
-> can give every 30 mins for 2-4 hrs
-> stop if stresses the patient

Risks: hyper reactive airways prone to bronchospasm during bronchoscopy and BAL procedures.

26
Q

What is appropriate longer term treatment for suspected airway disease in cats?

A

Reduce allergens?
Prednisolone po 2-3 weeks.
Consider inhaled fluticasone if improved.
- studies have confirmed route of delivery works
- some oral ingestion
If no response to pred…
- review case
– repeat test for – Mycoplasma/or treat?
have we ruled out lungworm?
- consider ciclosporin.

Risks: steroids are diabetogenic in cats. If side effects include polydipsia and polyuria treatment must stop!

27
Q

What is feline lungworm?

A
Aeleurostrongylus abstrusus
Paratenic hosts required (rodents, birds)
PPP 1-2 months
Most infected cats are asymptomatic
Clinical presentation
- usually young cats
- mild coughing but might  dyspnoea
- radiography: similar to inflammatory airway disease
Diagnosis:
- consider faecal flotation
- airway wash analysis 
Treatment trial: fenbendazole. 

This is the most likely airway parasite of cats.
Worming is never a bad thing to do in a cat that is coughing.

28
Q

What is Mycoplasma pneumonia in cats?

A

M felis associated with lower airway disease in cats
- might also cause URT signs
Not all infections are significant
- might be a contributing factor in feline inflammatory airway disease
Clinical signs: fever, cough, tachypnoea, lethargy.
Diagnosis: PCR on tracheal wash.
Treatment: doxycycline.

Remember that doxycycline carries the risks of significant side effects in cats!
Bear in mind – doxycycline can cause oesophageal stricture … (GI module).

29
Q

What is Mycobacterial pneumonia in cats?

A

M. bovis, M. microti.
Pneumonia represents late stage systemic spread of infection.
Early cutaneous signs:
- after bite from an infected vole or rodent
- non-healing sores or nodules +/- large LNs
Early GI signs:
- after ingestion eg contaminated milk
- vomiting, diarrhoea, weight loss, poor appetite
- lesion = inflammatory granulomas
Diagnosis: histopath and PCR- seek advice because we need to consider zoonotic aspects.