Feedback Flashcards

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1
Q

What is the purpose of a negative feedback loop?

A

When a system is disturbed, it returns it to normal by responding to the stimulus opposingly

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2
Q

What are negative feedback loops used for?

A
  • Maintain homeostasis
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3
Q

What is the purpose of a positive feedback loop?

A

Amplify a stimulus with a response,

- Stimulus increases due to responds

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4
Q

What are feedback loops used for?

A
  • Responding to internal/external stimuli

- Maintain internal environments

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5
Q

What part of the brain is responsible for thermoregulation?

A

Hypothalamus

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6
Q

How do our bodies respond to heat?

A
  • Blood vessels dilate
  • Increased breathing rate
  • Sweating
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7
Q

How do our bodies respond to cold?

A
  • Blood vessels constrict
  • Shivering
  • Increased metabolism by secretion of Thyroid hormone from the thyroid gland
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8
Q

What type of feedback loop is thermoregulation?

A

Negative feedback, temperatures are restored to their normal levels

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9
Q

Can the hypothalamus detect temperature changes on its own?

A

Yes

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10
Q

What type of feedback loop is ovulation?

A
  • Positive originally

- Negative after the formation of the Corpus luteum

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11
Q

Explain the positive feedback loop in ovulation.

A
  • The ovaries secrete estrogen
  • This triggers the hypothalamus to secrete gonadotropin releasing hormone and the anterior pituitary to release luteinizing hormone
  • The gonadotropin releasing hormone from the hypothalamus also stimulates the release of luteinizing hormone from the pituitary
  • Luteinizing hormone stimulates the ovaries to increase estrogen production, therefore the secretion of gonadotropin releasing hormone and luteinizing hormone also increase in the blood due to this positive feedback loop
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12
Q

Explain the negative feedback loop in ovulation.

A
  • The Corpus luteum is formed in the ovaries,
  • The Corpus luteum secretes progesterone in response to the luteinizing hormone,
  • Progesterone inhibits the release of gonadotropin releasing hormone and luteinizing hormone from the hypothalamus and anterior pituitary respectively,
  • Blood levels of these hormones decrease due to this negative feedback loop.
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13
Q

What type of feedback loop is labour preceding child birth?

A

Positive

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14
Q

Describe the labour preceding child birth feedback loop.

A
  • First, the loop is initiated by contractions of the uterus moving the baby’s head to the cervix
  • The pressure from the baby on the cervix stretches the cervix and stimulates nerves which send a message to the brain,
  • These impulses are received at the hypothalamus which secretes oxytocin into the blood capillaries of the pituitary gland and travels to the uterus,
  • When the uterus receives the oxytocin, the contractions increase and more pressure is applied to the cervix,
  • This creates a positive feedback loop as more signals are sent to the hypothalamus and more oxytocin is secreted,
  • This continues to dilate the cervix and push the baby at greater rates and intensities until the baby is delivered,
  • The positive feedback cycle ceases as the baby is born and no pressure is being applied to the cervix
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15
Q

What is pancreatic juice made of?

A
  • Digestive enzymes
  • Water
  • Sodium bicarbonate
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16
Q

What is the role of sodium bicarbonate in pancreatic juice?

A

Neutralize the stomach acid so that digestive enzymes can work

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17
Q

What is the role of insulin?

A

A hormone that tells cells to store sugar from the blood, and the liver to stop the production of sugar

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18
Q

What is the role of glucagon?

A

A hormone that tells cells and the liver to release glucose in the blood

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19
Q

Where are insulin and glucagon produced in the pancreas?

A

Islets of Langerhans

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20
Q

What type of feedback loop is blood sugar regulation?

A

Negative

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21
Q

What are some consequences of diabetes?

A
  • Heart attack
  • Stroke
  • Kidney failure
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22
Q

What does diabetes do to your body?

A
  • Insulin production is less/stopped
  • Blood glucose levels are too high
  • The blood hardens and prevents blood flow
23
Q

What is type 1 diabetes?

A

The body doesn’t produce any insulin because an autoimmune system destroys the insulin-producing cells in the body

  • Most commonly found in childhood,
  • 10% of all diabetes cases, typically found under 40yrs of age
24
Q

How does the body try to remove high levels of glucose in the blood in type 1 diabetes?

A

Through filtering in the kidneys, glucose expelled in urine

25
Q

What are the main symptoms of diabetes?

A
  • Frequent urination (body needs to release excess glucose)
  • Blurred vision (glucose builds up around the eye)
  • Tiredness (less energy from glucose)
  • Weight loss (no glucose in cells for energy so use fat deposit)
  • Thrush or genital itching (bacteria can survive better near glucose)
  • Slow-healing wounds (bacteria survives around the cut)
  • Thirst (water loss in the urine)
26
Q

How is type 1 diabetes treated?

A

Insulin

27
Q

What is type 2 diabetes?

A

Insulin is produced but either don’t work properly or there is not enough produced
- Around 90% of cases

28
Q

Why does insulin not work properly in type 2 diabetes?

A
  • Fat deposits build up in the cells, this means insulin cannot open cells to glucose since they no longer fit in the protein
29
Q

In type 2 diabetes what is the relationship between glucose levels and insulin levels initially?

A
  • Blood glucose increases
  • Insulin increase to counter this but is not very effective so blood glucose continues to rise
  • Insulin increases as glucose increases
30
Q

How quickly do symptoms arise for each type of diabetes?

A
  • Type 1: very quickly (weeks)

- Type 2: very slowly (years)

31
Q

How do you treat type 2 diabetes?

A
  • Controlled diet
  • Increased exercise
  • Medication
32
Q

How are the levels of water in the body maintained?

A
  • Hypothalamus detects low levels of blood water
  • Posterior pituitary releases ADH
  • ADH travels in the bloodstream to blood vessels and the kidneys
  • Kidneys increase water retention and prevent as much water from leaving in the urine
  • Blood vessels vasoconstrict to increase pressure and compensate for low blood pressure caused by lack of water
33
Q

What is a receptor?

A

A protein molecule where a signal molecule can bind

34
Q

What is a ligand?

A

The molecule that binds to a receptor, typically smaller than the receptor

35
Q

What are the steps to cell signalling?

A
  • Reception (receptor receives a signal)
  • Transduction (the receptor changes shape and passes on the signal to other molecules)
  • Response (how the cell responds to the singal)
36
Q

What are the types of signalling?

A
  • Direct contact
  • Paracrine signalling
  • Synaptic signalling
  • Endocrine signalling
  • Autocrine signalling
37
Q

What is direct contact signalling?

A

Signals between cells through the plasmata or gap junctions

38
Q

What is paracrine signalling?

A

A type of local signalling where ligands are ejected from cells to travel a short distance and bind to another cell,
- It must be local because ligands are rapidly absorbed and degraded

39
Q

What is synaptic signalling?

A

Neurotransmitters being the ligand between nerves

40
Q

What is endocrine signalling?

A

Signalling involving hormones

41
Q

What is autocrine signalling?

A

When a cell signals itself by releasing a ligand that rebinds to a receptor imbedded in the cell membrane or a peripheral protein
- If excessive growth factor is released by the cell could lead to cancer

42
Q

What are the three classes of protein receptors?

A
  • G-protein coupled receptor
  • Ion channel receptors
  • Enzyme couple receptors
43
Q

Do ligands use energy when it binds to a ligand transport channel?

A

No, these transport channels use passive transport/ facilitated diffusion

44
Q

What type of protein do hydrophobic ligands bind to?

A

Cytoplasmic protein receptors

45
Q

What type of protein do hydrophilic ligands bind to?

A

Transmembrane protein receptors

46
Q

What is signal trasnduction?

A

When the receptor receives a ligand, it undergoes some sort of change (usually a change in shape) and produces a signal inside the cell

47
Q

What do osteoblasts do?

A

Build up bone tissue

48
Q

What do osteoclasts do?

A

Break down bone tissue

49
Q

Where is PTH secreted and what is its function?

A
Secreted from the parathyroid gland
- Increases calcium levels in the blood when they are too low by activating osteoclasts and causing them to degrade bones to release calcium into the blood
(negative feedback)
- Stimulates osteoclast activity
- Inhibits osteoclast activity
50
Q

What is the function of calcitriol/ vitamin D?

A

Absorbs calcium into the gut

51
Q

What two hormones are used to increase blood calcium levels?

A
  • Calcitriol

- PTH

52
Q

How is the release of PTH stimulated from the parathyroid glands?

A

Low levels of calcium

53
Q

What is secreted when blood calcium levels are too high?

A

C cells/ parafollicular cells from the thyroid secrete Calcitonin

54
Q

What is the function of calcitonin?

A

Stimulate osteoblast activity/ build bone matrix to reduce blood calcium levels
(negative feedback)