Fécondation Flashcards

1
Q

Volume ejaculat

A

2 a 6ml

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2
Q

Qte spz ejaculat

A

40 à 600 millions

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3
Q

Sites de stockage

A

*cryptes paroi col utérus, cryptes endocervicales
*Isthme de la trompe (isthme tubaire)

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4
Q

Modification mb spz

A

*perte pt par GAG/albumine
*Perte cholestérol par albumine/lipopt VGF
*Clivage chaînes glucidiques glycopt mb par VGF
*Ajout pt lumière VGF asso spz

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5
Q

Hyper mobilité spz

A

Progression linéaire “flechante”
⤵️
Progression erratique (irréguliere)= coups de fouet

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6
Q

Chimio attraction hormone

A

Progestérone

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7
Q

Structure ZP

A

Mb épaisse
Transparente
Riche en glycopt
+Chaines heterodimeres ZP3,ZP2 ,ZP1
+Chaines oligosaccharides COS

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8
Q

Liaison primaire

A

*mannosidase ZP3 (mb plasmique spz)
*sp56 ZP3 (mb plasmique spz)
*sp95 ZP3 (partie protéique)

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9
Q

Réaction acrosomique

A

ZP3-sp95
⤵️
Aug Ca2+
⤵️
Activation phospholipase C
⤵️
Mod perméabilité Calcium
⤵️
Desorga cytosq actine/dislocation cortexe actine

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10
Q

Liaison secondaire

A

*sp17 ZP2
*SPAM1 ZP2

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11
Q

Liaison mb plasmique ovocyte, fusion gamètes

A

*integrine α6β1 ADAM2
*CD9 IZUMO

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12
Q

Mécanisme rapide

A

Pénétration spz
⤵️
Oscillations calciques
⤵️
Aug calcium intracellulaire ovocyte
⤵️
*Redistribution organites ovocyte
*Réaction corticale
*Initiation dpt embryo

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13
Q

Mécanisme lent

A

1er pic, migration granules corticaux, point fusion gamètes
=Rigidifie ZP

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