FATTY LIVER Flashcards

1
Q

Etiology dari terkumpulnya akumulasi TG meliputi..

A
  • De novo lipogenesis
  • Increased FA Uptake (obesity)
  • Reduced FA Oxidation
  • Reduced VLDL Secretion
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2
Q

ETHANOL akan diubah menjadi ACETALDEHYDE oleh..

A

Alcohol Dehydrogenase, Catalase, CYP2E1

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3
Q

ACETALDEHYDE bersifat toksik, makanya ia diubah menjadi ACETATE oleh enzim..

A

ALDEHYDE Dehydrogenase

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4
Q

Rasio NADH/NAD+ akan meningkat, dimana NADH….. dan NAD+….

A

NADH meningkat

NAD+ menurun

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5
Q

Efek dari rasio NADH/NAD+ yang meningkat ialah..

A
  • gangguan oxidasi
  • produksi TG ningkat
  • stress oksidatif
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6
Q

Tanda2 ALD dari National Institut of Alcoholism & Alcohol Abuse ialah..

A
  • Konsum alkohol >50gr/hari dalam waktu minimal 6 bulan
  • total bilirubin >3mg/dl
  • AST : 50-400U/L
  • rasio AST/ALT > 1,5
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7
Q

Simple STEATOSIS, FIBROSIS, SIROSIS, HCC merupakan tanda2 klinis dari…

A

NAFLD

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8
Q

Faktor risiko dari NAFLD ialah..

A
  • obesitas
  • DM II
  • Dyslipidemia
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9
Q

Secondary NAFLD disebabkan oleh

A

obat obatan

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10
Q

Diagnosis penunjang dari NAFLD bisa dilakukan :

A
  • imaging: USG !!
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11
Q

Managemen untuk pasien NAFLD ialah..

A
  • Lifestyle Modif : diet & olahraga!!
  • Farmakologi (tp blm diapprove fda) :
    vit E
    Pioglitazone
    Pentoxifylin
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12
Q

Entamoebic Histolytica dapat menyebabkan penyakit

A

Amoebic Liver Abscess ( ALA)

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13
Q

ALA sering dijumpai di daerah..

A

India, Asia tenggara, Afrika, Meksiko, Venezuela, dan Colombia

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14
Q

Kista dari E. Histolytica hancur dan menjadi Trophozoite di..

A

Usus Halus

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15
Q

Invasi mukosa usus oleh trophozoite E. Histolytice membentuk..

A

Flask-Shaped Ulcer

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16
Q

-Demam dan nyeri perut RUQ/ epigastrium
- gejala brlangsung selama 2 minggu
-hepatomegali dan nyeri
-biasanya pd laki2
merupkan tandai dari

A

Amoebic Liver Abcess

17
Q

Pada USG pasien ALA ditemukan tanda2 berikut :

A
  • Lesi HIPOECHOIC

- Internal echo di lobus kanan dkt diagragma

18
Q

Pada CT SCAN abdomen pasien ALA, ditemukan..

A
  • Lesi Hipoden

- Enhancement di perifer

19
Q

Di foto thoraks terlihat elevasi diafragma kanan, infiltrat/efusi/atelektase di lobus kanan bawah merupakan tanda2 dari..

A

ALA

20
Q

Obat untuk Amoebic Liver Abscess dapat ditemukan :

A
  • Metronidazole 750mg/8jam oral atau IV 7-10hari
  • Tinidazole 2gr/hari 5 hari
  • Intestinal amebecide :
    paramomycin
    diloxanide furoate
    lodoquinol