Fatty Acid Synthesis

Question 1

When does this process occur?

Answer 1

In the fed state when blood glucose levels are elevated

Question 2

Where does this process occur?

Answer 2

The cytosol

Question 3

What enzyme catalyzes the reaction of acetyl coa being converted to malonyl coa?

Answer 3

Acetyl-CoA carboxylase

Question 4

What promotes acetyl coa carboxylase?

Answer 4

Insulin

Question 5

What inhibits acetyl coa carboxylase?

Answer 5

Epinephrine and glucagon
Fatty acyl coa

Question 6

Why do epinephrine and glucagon inhibit ACC?

Answer 6

Epinephrine and glucagon stimulate protein kinase A to phosphorylate the active ACC, therefore inactivating it

Question 7

What are the ACC cofactors?

Answer 7

Biotinyl enzyme and HCO3-

Question 8

Enzymes used in order

Answer 8

All are found within fatty acid synthetase
KS
KR
HD
ER
AT & MT

Question 9

Steps of FA synthesis

Answer 9

1. condensation of precursors
2. reduction of the keto intermediate
3. dehydration of a secondary alcohol
4. reduction of a trans double bond
5. transfer of newly elongated chain

Question 10

What is acetyl coa used for in FA synthesis?

Answer 10

To prime the enzyme for further extension

Question 11

How many ATP molecules are required for the conversion of acetyl coa to malonyl coa?

Answer 11

2