fatty acid metabolism

Question 1

where does glycerol enter central metabolism

Answer 1

g3p

Question 2

beta oxidation of fatty acids main pathway

Answer 2

1. activation by formation of CoA derivative
2. transport into mitochondrion via the carnitine carrier system
3. oxidation by series of rxns in which the acyl chian is shortened by 2 carbons at a time (beta oxidation)

Question 3

activation

Answer 3

adenylation to drive synthesis of high energy thioester bond to coenzyme A

Question 4

where does the activation step happen

Answer 4

cytoplasm

Question 5

does transport into mitochondria consume energy

Answer 5

no

Question 6

what is the main regulated step of FA degradation

Answer 6

transport into the mitochondria

Question 7

what kind of double bond in beta oxidation reactions

Answer 7

trans

Question 8

steps of beta oxidation

Answer 8

1. dehydrogentaion 2. hydration 3. drhydrogenation 4. thiolytic cleavage

Question 9

how is FAD reoxidized

Answer 9

dump electrons into the ETC using electron-transferring flavoprotein

Question 10

per 2 unit C removed, how many acetyl coa

Answer 10

1

Question 11

per 2 unit C removed, how many nadh

Answer 11

1

Question 12

per 2 unit C removed, how many fadh2

Answer 12

1

Question 13

where does FA biosynthesis occur

Answer 13

cytoplasm

Question 14

FA biosynthesis activation enzyme

Answer 14

acetyl-coa carboxylase

Question 15

FA biosynthesis cofactor

Answer 15

biotin

Question 16

first committed step in FA biosynthesis?

Answer 16

acetyl coa -> malonyl-coa

Question 17

acetyl coa must be transported from ____ to ______ for FA biosynthesis

Answer 17

mitochondria to cytosol