Fatty Acid Degradation - Pathway

Question 1

Fatty acid + ATP + _____ + _____ (E) ⇔ _____ + _____ + _____

Answer 1

Fatty acid + ATP + CoA + Acyl CoA synthetase ⇔ Acyl CoA + AMP + PP_i

Question 2

Acyl CoA + _____ + _____ (E) ⇔ _____ + _____

Answer 2

Acyl CoA + carnitine + carnitine acyltransferase I (E) ⇔ acyl carnitine + CoA

Reverse reaction uses carnitine acyltransferase II

Question 3

Acyl CoA + E-FAD + _____ (E) → _____ + _____

Answer 3

Acyl CoA + E-FAD + acyl CoA dehydrogenase (E) ⇔ trans-∆²-Enoyl CoA + E-FADH₂

Question 4

trans-∆²-Enoyl CoA + _____ + _____ (E) ⇔ _____

Answer 4

trans-∆²-Enoyl CoA + H₂O + enoyl CoA hydratase (E) ⇔ L-3-hydroacyl CoA

Question 5

L-3-hydroacyl CoA + _____ + _____ (E) ⇔ _____ + _____ + _____

Answer 5

L-3-hydroacyl CoA + NAD⁺ + L-3-hydroacyl CoA dehydrogenase (E) ⇔ 3-ketoacyl CoA + NADH + H⁺

Question 6

3-ketoacyl CoA + _____ + _____ (E) → _____ + _____

Answer 6

3-ketoacyl CoA + CoA + beta-ketothiolase (E) → acetyl CoA + acyl CoA