FASD Flashcards
Prevalence of FASD in SA
13.6-20.9%, highest recorded prevalence in the world
What is a teratogen?
A factor that causes malformation in an embryo
Continuous alcohol exposure
- Light: less than 0.5oz a day
- Moderate: 0.5-0.99oz a day
- Heavy: more than 1oz a day
1oz = 2 drinks
Definition of binge drinking
Female: 4 drinks a session
Male: 5 drinks a session
Prenatal factors for FASD (6)
- Maternal health
- Critical period
- Dosage and duration
- Genetic make up
- Mother’s lifestyle
- Metabolising of alcohol, in mother
Postnatal risk factors
Social environment
What is a biomarker?
A biological marker of exposure to alcohol as a foetus.
Example of a biomarker
Fatty acid ethyl ester trapped in meconium
What is a biobehavioral marker?
Behavioural outcome linked to FASD where the neural substrates have been identified and can be studied directly
Pros of biobehavioral markers
It can be used to identify degrees of impairment and can improve diagnosis and treatment
Four different pathologies of FASD
- Fetal alcohol syndrome
- Partial FAS
- Alcohol related neurodevelopmental disorder
- Alcohol related birth defects
Diagnostic criteria for FAS (4)
- Prenatal exposure
- Deficits in central nervous system development and functioning
- Deficient growth pattern
- Craniofacial irregularities
Diagnostic criteria for PFAS (3)
- Prenatal alcohol exposure
- Some characteristic facial features
- Either CNS deficiencies OR cognitive/behavioural deficits OR physical growth symptoms
Diagnostic criteria for Alcohol Related Neurodevelopmental Disorder (2)
- Prenatal alcohol exposure
2. Deficits in CNS: development and/or functioning (cognitive + behavioural difficulties)
Diagnostic criteria for Alcohol Related Birth Defects (2)
- Prenatal alcohol exposure
2. Conventional physical abnormalities
Effects on brain development (2)
- An overall reduction in brain size, particularly the inferior parietal, frontal and perisylvian areas (implicated in language)
- Decreased white matter integrity, compromising internal brain communication