Family planning: Contraception Flashcards
Importance of family planning
For reproductive health, physical, mental and social well-being
Satisfying and safe sex life
Freedom to decide - when and how often to reproduce
Factors to be considered in contraceptives
Age
Parity
Future reproductive intention
Socioeconomic factors/ Education/ Sociocultural/ Peer influence
Sexual Hx
Motivation/ Compliance
Medical Hx
Method available
Government policies
2 statistical method to assess contraceptive efficacy
1: Pearl index
- Number of failures per 100 women-years of exposure
- Rate per HWY = (total no. of accidental pregnancies x 12 x 100) / total months of use
- disadvantage: assumes rate remains constant over period of time
2: Life table analysis
- calculates failure rate for a specified period
Types of family planning methods
- Coitus interruptus or withdrawal method
- Natural FP methods
- Hormonal methods
- Intrauterine devices
- Barrier methods
- Permanent methods
- Emergency Contraception
Oral contraceptive pills are divided into 3 types
- Combined pills (contains oestrogens & progestin)
- Mini pills (contains only progestin)
- Morning after pills (contain both hormones or each one alone in a higher dosage)
How do oral contraceptives work?
Oral contraceptives contain synthetic versions of 2 hormones produced naturally by the body: oestrogen and progestogen
- Steady levels of the 2 hormones will trick the pit gland that the woman is already pregnant, inhibiting the release of pituitary FSH and LH, thus inhibiting ovulation
- Progestogens thicken cervical mucus which blocks sperm penetration to uterus
- Progestogens induce endometrial thinning and atrophy to prevent egg from attaching
Types of OCPs
- Monophasic
- same oestrogen and progestogen composition for all 21 days - Biphasic
- 1st 10 days: 1 dose
- next 11 days: another dose - Triphasic
- dosage changes every 7 days for 21 days and repeats in next cycle
Non-contraceptive benefits of COC
- Lighter menstruation (more regular, less flow, less dysmenorrhea and anemia)
- Treats certain gynae conditions
- Reduce endometrial, ovarian CA
- Reduce ovarian cysts, uterine fibroids, endometriosis
- Reduce benign breast disease
- Increase BMD (Protects against osteoporosis)
- Improve CVS (Protects against atherosclerosis)
- Fewer ectopic pregnancy
Side effects of COCs
Estrogen excess
- N/V
- Headache**
- Edema
- Leg cramps
- Increase in breast size
- Chloasma (mask of pregnancy)
- Visual changes
- HTN
- Vascular headache
Estrogen deficiency
- Early spotting
- Hypomenorrhea
- Nervous
- Atrophic vaginitis -> painful intercourse
Progestogen
- Acne, facial pigmentation
- Weight gain
Others
- No protection against STIs
Major S/E of COCs
- CVS disease
- MI
- Ischaemic/haemorrhagic stroke
- Venous thromboembolism
-> Must stop COC 4 weeks before major Sx
-> Limited to current users presently, unrelated to duration of use - HTN
- Cacinogenecity
- Breast cancer
-> Risk up to 10 years before stopping
-> Risk stops 10 years after stopping
-> Increased risk if started COC before 20yo
- Cervical cancer - Liver disease
- benign hepatocellular adenoma
Absolute C/I to COC
(think of the major S/E)
- Smokers > 35 yo
- Thrombotic disorders
- CVA
- CAD
- Impaired liver function
- Hepatic adenoma
- Estrogen dependent malignancy: Breast, endometrium Ca
- Pregnancy, breastfeeding (due to increase risk of thromboembolism)
- Undiagnosed irregular genital tract bleeding
Combined patches: Ortho Evra
- Applied once weekly for 3 weeks
- Start D1 or within 1st week of menses
- S/E profile similar to OCPs
- 99% effective
Vaginal ring: Nuvaring
- Contains E + P
- Flexible, soft transparent ring
- 1 cycle use for 3 weeks
- Inserted into vagina, outside cervix
Progestogen only pill (POP)
- Estrogen free oral contraceptives containing low dose progesterone
- For women with S/E to oestrogen containing pills
- For women C/I to COC
Composition, administration and efficacy of POP
Levonorgestrel
- Taken daily, non-stop
- Less effective than COC
??If missed pills, shld start as soon as rmb
??If >3h delay, requires alternative contraceptive method for 48h or abstinence
Mode of action of POP
- Progestogens thicken cervical mucus which blocks sperm penetration to uterus
- Progestogens induce endometrial thinning and atrophy to prevent egg from attaching
- Inhibits ovulation in 50% of cycles
Advantages of POP
- Does not suppress lactation -> suitable for breastfeeding women***
- Suitable for those with medical C/I to estrogen containing pills
- Reversible
Disadvantages of POP
- Requires user motivation -> can lead to poor compliance
- Increased menstrual irregularity or stops completely
- Progestogenic side effects: mastalgia, bloatedness, headache, nausea
Progestogen-only Injectables: Depo Provera
- 150mg IM every 13 weeks (or 3 months) OR
- 300mg IM every 6 months
- Can be up to 2 weeks early or 4 weeks late
- Injected into buttock/ deltoid
- If there is abnormal PV bleed, exclude endometrial CA first
Advantages of progestogen-only injectables
- Convenient
- Highly effective
- Breastfeeding
- Shortens and lightens menstruation: good for menorrhagia, dysmenorrhea, Fe deficiency anemia and endometriosis
- Protection against ovarian/ endometrial CA
- Reduce risk of PID
- Used for those C/I to estrogen
- Decrease sickle cell crises
- No increase in VTE
Disadvantages of progesterone-only injectables
- Irregular bleeding pattern/ menstruation can stop completely
- Weight gain
- Short term can cause reversible loss in BMD (Osteopenia) but is regained after stopping injections
- No protection against STIs
- Delayed return to fertility: takes up to ~9 months to return to fertility after stopping injections, even longer in obese women
Contraindications of progesterone-only injectables
Absolute C/I
- Current breast cancer
- Pregnancy
Relative C/I
- Vascular Disease
- IHD/ Stroke
- Past breast CA
- Liver disease
- Undiagnosed vaginal bleeding
- SLE
Subdermal implants
Silicone rubber capsule filled with etonorgestrel inserted under the skin
- Nexplanon: 1 rod (non-biodegradable)
- High efficacy, better than female sterilisation
Mode of action + Frequency of Administration of subdermal implant
Sustained slow and steady release of progesterone
Prevents ovulation
Thickens cervical mucus -> hence poor sperm penetration
Thins endometrium
- Frequency of administration: once every 3 years
Advantages of subdermal implants
- High efficacy
- Long acting reversible contraception
- Breastfeeding
- Reduces dysmenorrhea/ovulation pain
- No risk of VTE/stroke/MI
- No effect on BMD
Disadvantages of subdermal implant
- Menstrual irregularities
- 1/3 infrequent bleeding
- 1/4 prolonged/frequent bleeding
- 1/5 amenorrhea - Acne
- Insertion/Removal (refer to next card)
- Reduced efficacy in obese (high BMI) patients