Family: Parvoviridae, Canine Parvovirus Flashcards
What is one of the most infectious diseases of dogs?
What are the 3 antigenic variants of that disease?
Canine Parvovirus 2 (CPV-2)
CPV-2a, CPV-2b, CPV-2c
Transmission of CPV-2
Oro-nasal exposure to contaminated feces
In-utero infection
Contact with contaminated fomites
The 3 most important pathogenesis forms of CPV-2
Enteritis
Myocarditis
Panleukopenia
Enteritis pathogenesis of CPV-2
Infects the germinal epithelium of the intestinal crypts, causing destruction and collapse of the epithelium
No replacement of cells lost from tip of villus
Villi shortened
Myocarditis pathogenesis of CPV-2
Develops from infection in-utero or from pups
3 age related syndrome of CPV-2
2-12 days = generalized neonatal disease; uncommon
3-8 weeks = myocarditis
2-4 months = enteritis and panleukopenia; most common
Diagnosis of CPV-2
Serology (antibody detection) is not the best method to test CPV, because most dogs have been vaccinated, or have been previously exposed to CPV
Vaccination for CPV-2
MLV recommended at 6-8, 10-12, and 14-16 weeks of age, followed by a boost administered 1 year later and then every 3 years
Because of potential damage by CPV to myocardial or cerebellar cells, inactivated rather than MLV are indicated in pregnant dogs or colostrum deprived puppies vaccinated before 6-8 weeks of age