Family: Parvoviridae, Canine Parvovirus Flashcards

1
Q

What is one of the most infectious diseases of dogs?

What are the 3 antigenic variants of that disease?

A

Canine Parvovirus 2 (CPV-2)

CPV-2a, CPV-2b, CPV-2c

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2
Q

Transmission of CPV-2

A

Oro-nasal exposure to contaminated feces
In-utero infection
Contact with contaminated fomites

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3
Q

The 3 most important pathogenesis forms of CPV-2

A

Enteritis
Myocarditis
Panleukopenia

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4
Q

Enteritis pathogenesis of CPV-2

A

Infects the germinal epithelium of the intestinal crypts, causing destruction and collapse of the epithelium
No replacement of cells lost from tip of villus
Villi shortened

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5
Q

Myocarditis pathogenesis of CPV-2

A

Develops from infection in-utero or from pups

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6
Q

3 age related syndrome of CPV-2

A

2-12 days = generalized neonatal disease; uncommon
3-8 weeks = myocarditis
2-4 months = enteritis and panleukopenia; most common

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7
Q

Diagnosis of CPV-2

A

Serology (antibody detection) is not the best method to test CPV, because most dogs have been vaccinated, or have been previously exposed to CPV

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8
Q

Vaccination for CPV-2

A

MLV recommended at 6-8, 10-12, and 14-16 weeks of age, followed by a boost administered 1 year later and then every 3 years
Because of potential damage by CPV to myocardial or cerebellar cells, inactivated rather than MLV are indicated in pregnant dogs or colostrum deprived puppies vaccinated before 6-8 weeks of age

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