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Immunology (By: Ben + Dustin) > Factors and receptors > Flashcards

Factors and receptors Flashcards

1
Q

CD3

A

T-cell co-receptor helps to activate the cytotoxic T-Cell

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2
Q

CD4

A

receptor for Helper t cells

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3
Q

CD5

A

CD5+ B1 B cell marker

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4
Q

CD8

A

Cytotoxic t cell receptor

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5
Q

CD11

A

marker of dendritic and macrophages

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6
Q

CD28

A

costimulatory receptor on T cells that binds to CD80 and CD 86

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7
Q

CD40

A

costimulatory receptor on B cells that binds to CD40L on T helper cells

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8
Q

CD56

A

NK and NKT cell marker

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9
Q

CD59

A

protectin (inhibits complements system via C9 polycomplex)

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10
Q

IL 1

A

secreted by antigen presenting cells on helper t cells to help their activation

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11
Q

IL 2

A

T cell growth factor upon itself to help activation

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12
Q

IL4

A 
induces differentiation of naive helper T cells (Th0 cells) to Th2 cells
IL-4 induces B-cell class switching and antibody production
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13
Q

IL 5

A

T helper 2 cell cytokine, helps Ig production of IgE and IgA

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14
Q

IL 6

A

most important. T helper 1 cell cytokine, used to inflammation and acute phase. pro-inflam and very helpful for fighting infection

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15
Q

IL 7

A

bone marrow growth factor

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16
Q

IL 8

A

It induces chemotaxis in target cells, primarily neutrophils and also other granulocytes,
IL-8 also induces phagocytosis once they have arrived

17
Q

IL 10

A

an anti-inflammatory cytokine, secreted by t reg cells. inhibits T helper 1 cells

18
Q

IL 12 and IL 18

A

secreted by macrophage, apc and involved in the differentiation/activation of naive T cells into Th1 cells.

It stimulates the production of IFN-γ and tumor necrosis factor-alpha (TNF-α) from T cells and natural killer (NK) cells

19
Q

IL 13

A

used with T helper type 2 (Th2) cells,that is a mediator of allergic inflammation and disease. IgE mainly

20
Q

IL 17

A

a pro-inflammatory cytokine produced by T-helper cells

Signaling from IL-17 recruits monocytes and neutrophils to the site of inflammation in response to invasion by pathogens, similar to Interferon gamma. In promoting inflammation, IL-17 acts synergistically with tumor necrosis factor and interleukin-1

21
Q

IL 21

A

cytokine induces cell division/proliferation in its target cells including natural killer (NK) cells and cytotoxic T cells

22
Q

CD 80

A

found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival.

23
Q

cd 86

A

on T cell and other antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival.

24
Q

cd40

A

expressed by antigen presenting cells, including dendritic cells, B cells and macrophages

25
Q

cd40L

A

expressed on activated T helper 2 cells

Immunology (By: Ben + Dustin) (12 decks)

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