Factors and receptors Flashcards
CD3
T-cell co-receptor helps to activate the cytotoxic T-Cell
CD4
receptor for Helper t cells
CD5
CD5+ B1 B cell marker
CD8
Cytotoxic t cell receptor
CD11
marker of dendritic and macrophages
CD28
costimulatory receptor on T cells that binds to CD80 and CD 86
CD40
costimulatory receptor on B cells that binds to CD40L on T helper cells
CD56
NK and NKT cell marker
CD59
protectin (inhibits complements system via C9 polycomplex)
IL 1
secreted by antigen presenting cells on helper t cells to help their activation
IL 2
T cell growth factor upon itself to help activation
IL4
induces differentiation of naive helper T cells (Th0 cells) to Th2 cells IL-4 induces B-cell class switching and antibody production
IL 5
T helper 2 cell cytokine, helps Ig production of IgE and IgA
IL 6
most important. T helper 1 cell cytokine, used to inflammation and acute phase. pro-inflam and very helpful for fighting infection
IL 7
bone marrow growth factor
IL 8
It induces chemotaxis in target cells, primarily neutrophils and also other granulocytes,
IL-8 also induces phagocytosis once they have arrived
IL 10
an anti-inflammatory cytokine, secreted by t reg cells. inhibits T helper 1 cells
IL 12 and IL 18
secreted by macrophage, apc and involved in the differentiation/activation of naive T cells into Th1 cells.
It stimulates the production of IFN-γ and tumor necrosis factor-alpha (TNF-α) from T cells and natural killer (NK) cells
IL 13
used with T helper type 2 (Th2) cells,that is a mediator of allergic inflammation and disease. IgE mainly
IL 17
a pro-inflammatory cytokine produced by T-helper cells
Signaling from IL-17 recruits monocytes and neutrophils to the site of inflammation in response to invasion by pathogens, similar to Interferon gamma. In promoting inflammation, IL-17 acts synergistically with tumor necrosis factor and interleukin-1
IL 21
cytokine induces cell division/proliferation in its target cells including natural killer (NK) cells and cytotoxic T cells
CD 80
found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival.
cd 86
on T cell and other antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival.
cd40
expressed by antigen presenting cells, including dendritic cells, B cells and macrophages
cd40L
expressed on activated T helper 2 cells
