Extras Flashcards
Young person seronegative arthralgia
salmon pink rash
ferritin high
fevers and lymohadenopathy
adult onset stills
features sjogrens
dry eyes, mouth, vagina
lymphoma risk increase
sensory neuropathy
raynauds
RTA
arthralgia
SErology in sjogren’s
RF in ALL!
Ro 70% (only 10% RA) La30% SChirmers test under 10mm in 10 mins low C4 hypergammaglobulinaemia
Benefit of febuxostat over allopurinol
NOT renally excreted
No hypersens syndrome
Is HCV arthropathy an indication for antivirals
no
dermatomyositis most common malig
lung and ovarian
allopurinol hypersens
HLA B 58:01
malig with TNF alpha
NOT lymphoma
just non melanoma skin cancers
U3RNP vs U1 RNP
U3 RNP is a scleroderma Ab- skeletal muscle and more PAH
U1 RNP in MCTD or SLE
What predicts mortality in scleroderma
extent of disease on HRCT!
Au research
Even better than FVC
but NO value in serial HRCTs- matched by PFTs usually
why do you worry about high steroid doses in scleroderma
increase risk renal crisis
also NSAIDS
Bosentan effect on hand ulcers
no effect on healing but stop new ulcers
What agent is useful in scleroderma lung
cyclophosphamide
Most common interstitial lung disease pattern in scleroderma
NSIP
What predicts mortality in scleroderma
extent of disease on HRCT!
Au research
Even better than FVC
but NO value in serial HRCTs- matched by PFTs suually
Type of endothelin receptor antagonists
non selective- receptors A and B- macicentan and bosentan
selective - receptor A- ambrisentan
urate crystals look like
needle shaped
neg biref
calcium oxalate crystals look like
bipyrmaidal crystals
neg birefring
calcium pyrophosphate
rhomboid crystals
weak positive birefringence under polarised light
calcium hydroxyapatite crystals
small non birefringent
only see with EM
does sjogrens cause hypergammaglobulinaemia
hypogammaglobulinaemia in 80%
do a kappa lambda ratio to check are polyclonal!!!
