Antibodies- simplified Flashcards
Anti-Ro
Sjogren’s syndrome
In lupus, risk of congenital heart block
Anti-La
Sjogren’s
Neonatal lupus
Anti Jo-1
Polymyositis
associated with pulmonary fibrosis and symmetrical polyarthritis
LUNGS AT RISK
Anti Scl-70
diffuse cutaneous systemic sclerosis
Increase risk ILD
Lower risk renal involvement
Anti-centromere
Limited cutaneous systemic sclerosis
Anti-Sm
SLE and in particular renal and CNS disease
U1RNP
Mixed connective tissue disease
dsDNA
SLE
Drug induced lupus WHEN associated with TNF blockers
RNA polymerase
systemic sclerosis
Suggests renal disease or severe skin involvement
Th/To
limited cutaneous systemic sclerosis
poor outcome
pulmonary hypertension
PM-SCl
polymyositis/scleroderma overlap syndrome
Anti-Mi2
Dermatomyositis
- shawl sign
- good steroid response
- better prognosis
Anti-SRP
Polymyositis or Necrotising myopathy -Rapid onset -severe weakness -poor response to steroids -cardiac involvement
pANCA these days means…
Anti-MPO
cANCA these days means….
Anti-PR3
Anti-PR3
Wegner's (90%) Microscopic polyangitis (30%)
Anti-MPO
Churg Strauss (50%) Microscopic polyangiitis (70%) Wegner's (10%) Primary sclerosing cholangitis (most) IBD
RF
RA
Anti-CCP
RA
tRNA synthase
antisynthetase syndrome- up to 30% PM or DM are this
associated with acute onset, constitutional symptoms, myositis, Raynaud’s, mechanics hands, non errosive arthritis, and ILD THAT DRIVES THE MORBIDITY AND MORTALITY
Often also Anti Jo positive
treat with steroids and a sparin g agent, IV cyclo if lung disease
biopsy findings
DM- perifasccular not infiltrating, more CD4 T cells (think skin, surface, perifascicular)
PM and IBM infiltrate INTO fascicles and more CD8 cells
inclusion bodies only 20-30% on biopsy
MRI can help distinguish- inflamm throughout muscle rather than along planes in DM
anti 200/100 Ab
recognise HMG coA reductase protein in statin induced muopathy
