Extracorporeal therapies for blood purification

Question 1

Extracorporeal therapies for blood purification

Answer 1

Chapter 180, CCM 3rd edition

Question 2

When should extracorporeal therapy be used for toxicants?

Answer 2

the toxicant is amenable to removal by ECT; removal of the toxin diminishes the potential for morbidity; removal by ECT exceeds the potential for endogenous removal; and removal enhances the likelihood of survival.

Question 3

For what substances is diffusive clearance most effective?

Answer 3

removal of small (<500–1000 Da), water-soluble solutes, with a low degree of protein binding (<80%).

Question 4

What is haemoperfusion and when is it most effective

Answer 4

effective for removing large molecules (>10,000 Da) or highly protein bound
involves - blood being perfused across a charcoal or absorbent cartridge.

Question 5

When is plasmapheresis/TPE appropriate

Answer 5

Plasmapheresis allows for the removal of larger (>50,000 Da) or highly protein-bound (>95%) solutes that exist within the plasma compartment.