Extracellular Matrix and Wound Healing Flashcards
1
Q
Integrins
A
- consists of a heterodimer between an alpha and beta integrin
- glycoprotein
- anchor the ECM to the cell membrane and the cytoskeleton
- are receptors that have ligands on either side of the cell membrane, and those ligands may be adaptor proteins
- many mutations in integrin genes are lethal
2
Q
actin-linked cell-matrix junction
A
uses integrins to anchor actin filaments in cell to extracellular matrix
3
Q
hemidesmosome
A
uses integrins to anchor intermediate filaments in a cell to extracellular matrix
4
Q
epithelial tissue cells
A
connected by cell-cell junctions and have a limited ECM
- ECM is the basal lamina/basement membrane
- usually “outer” layer like skin
5
Q
fibroblasts
A
secrete extracellular matrix
6
Q
lamins
A
- heterotrimer: alpha, beta, and gamma subunits
- glycoprotein
- stay near the cell membrane and help cells stick together
- helps organize basal membrane
- helps with adhesion and migration of cells
7
Q
collagen
A
- makes up majority of ECM
- triple helix = fibril
- glycoprotein
- can form sheets
- can cross the cell membrane
- can be protein part of proteoglycans
- can be associated with fibrils (hanging off other fibers)
- I and III that form fibers are most prevalent in cell
8
Q
ehlers danlos syndrome
A
- associated with collagen I and V
- hypermobility
- elastic but fragile skin: easily torn and may scar easily
9
Q
alport syndrome
A
- associated with collagen IV (basal lamina)
- progressive kidney failure: decreased filtering function of glomeruli
- hearing loss: can hear but message isn’t transmitted to brain
- eye deformities: lens shape or retina color can change but no loss of function
10
Q
proteoglycans
A
- sugar-modified peptides (more sugar than protein)
- very big
11
Q
decorin
A
- type of proteoglycan
- interacts with and regulates collagen fibers
12
Q
versican
A
- type of proteoglycan
- interact with elastins and influences cell migration
- important in wound healing
13
Q
aggrecan
A
- type of proteoglycan
- found in cartilage
14
Q
syndecans
A
- only transmembrane proteoglycan
- intracellular domain interacts with actin (actin-linked cell matrix junction)
15
Q
hyaluronan (HA)
A
- sugar that is on the proteoglycans
- only a sugar, but can interact with other proteins
- very hydrophilic, like to interact with water
- take up a lot of space
