Extracellular matrix Flashcards
1
Q
What affected to binding of integrin?
A
Ca2+ and Mg+
2
Q
How many different types of integrin?
A
24
23 bind to actin
1 bind to intermediate fillaments
3
Q
What is ehlers- danlos?
A
- Skin lacks tensile strength
- Do to a defect in collagen III
- Can cause arterial rupture
4
Q
What does integrin do?
A
- Transmembrane receptor
- Links extracellular martix to the cytoskeleton
5
Q
What sequence does fibronectin use to bind to integrin?
A
Arg, Gly, Asp
6
Q
Where is laminin found?
A
In the basal lamina
7
Q
What is the structure of laminin?
A
- Sword shape
- Binds to matrix (collagen)
- Binds to cells
- Binds to integrin
- α β γ chains
8
Q
How is elastin made?
A
1) Tropoelastin –> elastin
- By lysyl oxidase
- Removes amine
2) Elastic –> elastin fibre
- Form crosslinks
- Elastin laid over fibrillin
9
Q
What is the structure of fibronectin?
A
- Dimer linked by disulphide bonds
- Self- association domain (can cross link)
- Can bind to collagen in the extracellular matrix
- Binds to integrin
10
Q
What does lysyl oxidase do?
A
Remove amine from tropoelastin to elastin
