Extra Diabetes

Question 1

LADA

Answer 1

The presence of elevated levels of pancreatic auto-antibodies in patients with ‘recently diagnosed’ diabetes who do not initially require insulin. E.g. slowly progressive type 1/type 1.5

Question 2

what are peoplem with LADA often misdiagnosed with

Answer 2

T2DM

Question 3

what is LADA associated with

Answer 3

• Male, young adults
• Usually non-obese
• Auto-antibody positive
• Associated autoimmune conditions
• Non-insulin requiring at diagnosis
• Sub optimal control on oral agents

Question 4

wolfram syndrome

Answer 4

DIDMOAD: diabetes insipidus, diabetes mellitus, optic atrophy, deafness, neurological abnormalities.

Question 5

onset and inheritance of DIDMOAD

Answer 5

Rare, autosomal recessive disorder with childhood onset.

Question 6

Barbet-Biedl Syndrome

Answer 6

• Often very obese
• Ciliopathic genetic disorder, causes polydactyly, hypogonadal, visual impairment, hearing impairment, mental retardation and diabetes

Question 7

polyglandular endocrinopathy

Answer 7

multiple endocrine gland insufficiencies

types 1 and 2

Question 8

polyglandular endocrinopathy type 1

Answer 8

• T1DM
• addison’s
• vitiligo
• 1y hypogonadism
• 1y hypothyroidism
• coeliac disease

Question 9

polyglandular endocrinopathy 2

Answer 9

• persistent chronic fungal infection due to mild immune deficiency - mucocutaenous candidiasis
• any of the type 1 conditions
• primary hypoparathyroidism
• pernicious anaemia
• alopecia