Extra Conditions Flashcards
(125 cards)
Red meat and alcohol can be risk factors for what condition due to purine emphasis?
Gout
What condition is an abnormal purine metabolism leading to uric acid accumulation?
Gout
When uric acid accumulates in gout, what do they become?
Monosodium urate crystals (tophus/tophi)
What occurs with gout?
Recurrent acute joint inflammation leading to destruction and fibrosis
Over 90% of the cases of gout is what kind?
Primary - hyperuricemia
What is the hypothesized cause of primary gout?
Enzyme defects
With primary gout, what accumulates in the blood?
Uric acid
What is secondary gout?
Gout that is secondary to another disease or from drug exposure
What are examples of some causes of secondary gout?
Renal disease leukemia, multiple myeloma, diuretics
What is the cause of the inflammation of gout?
Failed crystal phagocytosis
What is the usual age of those with gout?
Over 30
Gout usually occurs among which gender?
Males
What is the most common location for gout inflammation?
Hallux (MTP) aka podagra
About what percent of the population is affected by gout?
1%
The historical name, “Kings Disease”, is associated with what condition?
Gout
Monoarticular inflammation is characteristic of what condition?
Gout
What is the first stage of gout?
Asymptomatic hyperuricemia
What is the second stage of gout?
Acute gouty arthritis causing erythema
What is the third stage of gout?
Repeated chronic tophaceous arthritis that fails to resolve itself between cycles
20% of those with gout die from what issue?
Renal failure (gouty nephropathy)
What are other names for pseudogout?
Chondrocalcinosis or Calcium Pyrophosphate Deposition Disease (CPDD)
What causes pseudogout?
Altered pyrophosphate metabolism
Are most cases of pseudogout inherited?
No, most commonly sporadic
What is the usual location for pyrophosphate crystal deposition of pseudogout?
Knee, wrist, shoulder, hip, elbow, ankle