Extra

Question 1

colchicine used for?

Answer 1

1st line treatment of hereditary fever disorders
and gout

Question 2

colchicine MoA?

Answer 2

inhibits NALP3 inflammasome
reduce caspase1 activation
-> reduced IL-1b release

also inhibits neutrophil migration

Question 3

colchicine SEs?

Answer 3

GI: nausea, vomiting, diarrhoea

… neuropathy, myelosup, liver and kidney…

Question 4

colchicine contraindications?

Answer 4

eGFR <10
cardiac/ GI disease

Question 5

MTX used for?

Answer 5

2nd line AOSD/ conventional synthetic DMARD for RA

Question 6

MTX MoA?

Answer 6

Inhibits dihydrofolate reductase -> decreased DNA synthesis and cell proliferation

Question 7

MTX SEs?

Answer 7

infections
liver tox
renal
GI

Question 8

MTX contraindications?

Answer 8

Active infection; ascites; immunodeficiency syndromes; significant pleural effusion

Question 9

Adalimumab used for?

Answer 9

TNF bo DMARD for RA

Question 10

Adalimumab MoA?

Answer 10

binds TNFa and blocks effects -> reduce inflammation

Question 11

Adalimumab SEs?

Answer 11

ADAs

Question 12

Adalimumab contraindications?

Answer 12

Moderate or severe HF
severe infections

Question 13

Diclofenac (NSAID) used for?

Answer 13

1st line
AOSD
gout
OA

Question 14

Diclofenac (NSAID) MoA?

Answer 14

inhibits COX and reduced PG synth -> reduced inflammation and pain

Question 15

Diclofenac (NSAID) SEs?

Answer 15

GI: perforation, bleeding

CV risk: COX2 eg celecoxib

Question 16

Diclofenac (NSAID) contraindictaions?

Answer 16

Hypersensitivity to diclofenac or any other NSAIDs,
history of GI bleeding or ulcer,
severe renal/ hepatic impairment,
pregnancy