External Ocular Signs of Systemic Disease Flashcards

1
Q

What are external ocular signs of systemic disease?

A

Physical changes in the eyes or surrounding tissues that indicate underlying systemic conditions.

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2
Q

What are common systemic diseases associated with external ocular signs?

A

Diabetes, hypertension, thyroid disease, autoimmune disorders, and infections.

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3
Q

What is xanthelasma, and what does it indicate?

A

Yellow plaques on the eyelids, often associated with hyperlipidaemia.

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4
Q

What is arcus senilis, and what systemic condition can it suggest in younger patients?

A

A grey-white ring around the cornea, which may indicate hyperlipidaemia in younger individuals.

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5
Q

What ocular findings are associated with Graves’ disease?

A

Proptosis, lid retraction, periorbital oedema, and conjunctival redness.

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6
Q

What is Kayser-Fleischer ring, and what condition is it associated with?

A

A brownish ring at the corneal margin caused by copper deposition, seen in Wilson’s disease.

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7
Q

What is episcleritis, and what systemic diseases can it indicate?

A

Inflammation of the episclera, associated with rheumatoid arthritis, inflammatory bowel disease, and other autoimmune conditions.

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8
Q

What is scleritis, and what systemic conditions can it be linked to?

A

Painful inflammation of the sclera, often associated with systemic vasculitis (e.g., granulomatosis with polyangiitis).

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9
Q

What is a subconjunctival haemorrhage, and what systemic condition can it indicate?

A

Bleeding under the conjunctiva, sometimes associated with hypertension or clotting disorders.

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10
Q

What are Roth spots, and what systemic condition are they associated with?

A

Retinal haemorrhages with white centres, often seen in infective endocarditis or leukaemia.

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11
Q

What are the ocular findings in diabetes?

A

Retinal microaneurysms, haemorrhages, exudates, neovascularisation, and diabetic macular oedema.

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12
Q

What are the ocular signs of hypertension?

A

Retinal arteriolar narrowing, AV nicking, cotton wool spots, and haemorrhages.

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13
Q

What are the ocular signs of anaemia?

A

Conjunctival pallor and retinal haemorrhages.

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14
Q

What is hypertensive retinopathy, and how is it graded?

A

Retinal changes caused by chronic hypertension, graded using the Keith-Wagener-Barker classification.

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15
Q

What are the ocular findings in sarcoidosis?

A

Uveitis, conjunctival granulomas, and optic nerve involvement.

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16
Q

What are the ocular findings in systemic lupus erythematosus (SLE)?

A

Keratoconjunctivitis sicca, retinal vasculitis, and optic neuropathy.

17
Q

What are the ocular signs of vitamin A deficiency?

A

Night blindness, Bitot’s spots, and corneal xerosis.

18
Q

What are the ocular findings in Marfan syndrome?

A

Ectopia lentis (lens dislocation) and myopia.

19
Q

What are the ocular manifestations of HIV/AIDS?

A

Cotton wool spots, cytomegalovirus (CMV) retinitis, and Kaposi sarcoma involving the eyelids.

20
Q

What is Horner’s syndrome, and what systemic condition can it indicate?

A

Ptosis, miosis, and anhidrosis, often caused by a lesion along the sympathetic pathway (e.g., apical lung tumour).

21
Q

What are the ocular signs of tuberculosis?

A

Uveitis, choroiditis, and optic neuritis.

22
Q

What are the ocular signs of rheumatoid arthritis?

A

Keratoconjunctivitis sicca, scleritis, and episcleritis.

23
Q

What are the ocular manifestations of multiple sclerosis?

A

Optic neuritis, internuclear ophthalmoplegia, and nystagmus.

24
Q

What are cherry-red spots in the retina, and what systemic conditions are they associated with?

A

Seen in Tay-Sachs disease and central retinal artery occlusion.

25
Q

Why is it important to recognise external ocular signs of systemic disease?

A

Early detection of systemic conditions can lead to timely diagnosis and management, improving patient outcomes.