export_zoonotic bacteria ii Flashcards
Borrelia features
Neither Gram-positive nor negative
Long spirochetes
Fastidious, microaerophilic
Borrelia disease
Lyme disease Relapsing fever (endemic or epidemic)
Species causing lyme disease
Borrelia burgdorferi
Lyme disease reservoirs
Mice
Deer
Lyme disease vector
Ixodes (hard tick)
Disease stages of lyme disease
Early stage 1
Early stage 2
Late, stage 3
Early stage 1 lyme disease
Localized infection
Bull’s-eye rash
Malaise, fever, headache, fatigue
Early stage 2
Disseminated infection
3-5 weeks after bite
Bacteremia, myalgia, cardiac dysfunction, signs consistent with meningitis/encephalitis
Late, stage 3 lyme disease
Persistent infection
Arthritis
One or more joints affected, skin discoloration, neuro complaints
Treat lyme disease
Doxycycline or amoxicillin
Types of relapsing fever
Epidemic
Endemic
Epidemic relapsing fever cause
Borrelia recurrentis
Louse-borne
Endemic relapsing fever cause
Borrelia hermsii
Tick-borne
Relapsing fever pathogenesis
Dissemination
Ag variation
Febrile and afebrile cycles
Difference between endemic and epidemic relapsing fever
Epidemic form is NOT a zoonotic disease
Transmission from human to human via louse
Relapsing fever symptoms
Chills, fever, headache
Hepatosplenomegaly
Several relapses may occur
Diagnose relapsing fever
Giemsa stained blood smear
Treatment for relapsing fever
Tetracycline or erythromycin
Rickettsia features
Very small Gram-negative coccobacilli
Obligate intracellular pathogen, facilitate uptake into host cells
Disease caused by Rickettsia that we need to know, and vector
Rocky mountain spotted fever
Dog tick
RMSF symptoms
Rash and fever
Pink, non-itchy lesions that become raised and spread to torso
RMSF untreated
DIC, pulmonary edema, renal failure, GI hemorrhage
RMSF treatment
Tetracycline (doxycycline)
Ehrlichiosis causative agents
Ehrlichia and Anaplasma
Ehrlichia features
Gram-negative, intracellular pathogens
Parasitize monocytes and granulocytes
Two types of Ehrlichia
Ehrlichia chaffeensis
Anaplasma phagocytophilium
Disease caused by Ehrlichia chaffeensis
Human monocytic ehrlichiosis (HME)
Disease caused by Anaplasma phagocytophilium
Human gradulocytic ehrlichiosis (HGE)
“Anaplasmosis”
HME vector
Lone Star Tick
HME reservoir
White tailed deer
HGE vector
Ixodes
HGE reservoir
Variety of small mammals
Ehrlichiosis disease
Most are asymptomatic or present as a non-specific viral illness
Severe ehrlichiosis disease
Multisystem zoonosis
Malaise, fever, headache
Sometimes petechial rash
Respiratory distress, CNS dysfunction
Diagnose ehrlichiosis
Serology
Treat ehrlichiosis
Tetracycline (doxycycline)
Query (Q) fever causative agent
Coxiella burnetii
Coxiella burnetii features
Gram-negative, pleomorphic bacteria
Obligate intracellular
Small-cell and large-cell variants
Small-cell variants of Coxiella features
Resistant to high temperature, osmotic pressure, and UV light
Can survive in environment for months
Q fever reservoirs
Farm animals, dogs, cats
Forms of Q fever
Acute
Chronic
Acute Q fever
1/2 asymptomatic
General “flu-like” disease
Fever, chills, malaise, headache
Pneumonia
Chronic Q fever
Mainly as endocarditis or hepatitis
Acute signs general absent
Treatment of Q fever
Tetracycline (doxycycline)
Prevent Q fever
Inactivated, whole cell vaccine
Bartonella features
Small, slightly curved, Gram-negative rods
Diseases caused by Bartonella spp.
Trench fever (Bartonella quintana) Cat scratch fever (Bartonella henselae)
Trench fever vector
Lice (feces)
Trench fever disease
Relapsing fever, headache, dizziness
Not considered fatal
Treat trench fever
Aminoglycoside (gentamycin) or macrolide (erythromycin)
Cat scratch fever vector
Cat
Flea (feces)
Cat scratch fever disease
Fever
Lymphadenopathy
Papule at site of inoculation
Treat cat scratch fever
Generally not needed
If needed, azithromycin is recommended
RMSF rash
Centripetal spread
Trench fever rash
None
Q fever rash
None
Cat scratch fever rash
Papule at site of inoculation
Ehrlichiosis rash
~33%
Malaria fever
Every 2-3 days
Lasts 24 hours
Brucellosis fever
Daily
Fever recurrence in the evening
Relapsing fever fever
Every 7-10 days
Lasts 7-10 days