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Micro 5 > export_circulatory viruses i only ebv > Flashcards

export_circulatory viruses i only ebv Flashcards

1
Q

EBV diseases

A

Mono
Oral hairy leukoplakia

Burkitt’s lymphoma

Hodgkin’s disease

Nasopharyngeal carcinoma

PTLD

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2
Q

EBV virus family and features

A

Herpesviridae
Enveloped, dsDNA

Uses C3d component of complement for attachment and entry, replicates within epithelial and B cells

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3
Q

Latent membrane protein 1

A

6 transmembrane-spanning domains
CD40 homologue

Constitutively active receptor

Increased growth and suppressed apoptosis

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4
Q

Latent membrane protein 2

A

Increased growth of B cells

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5
Q

Epstein Barr virus nuclear Ag 1

A

Transactivation of EBV transforming genes

Inhibit apoptosis

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6
Q

Mono symptoms

A

Fever, malaise, splenomegaly

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7
Q

Biochemical marker of mono

A

Heterophile Abs

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8
Q

Pathogenesis of mono

A

Immune targeting of infected B cells

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9
Q

Mono diagnosis

A

Mono spot test (RBC agglutination)
Abs to EBV (IgM to viral capsid Ag)

Downey cells

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10
Q

Treatment of mono

A

Rest and hydration

Avoiding strenuous activity (splenic rupture)

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11
Q

Oral hairy leukoplakia

A

Typically in immunocompromised individuals

Active EBV replication

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12
Q

Oral hairy leukoplakia treatment

A

Antiherpetic drugs

Podophyllin resin

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13
Q

Cause of Burkitt’s lymphoma

A

Genetic translocation of MYC gene into Ig gene resulting in high levels of MYC in these B cells
Highly associated with EBV

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14
Q

Co-factors for Burkitt’s lymphoma

A 
Chronic malaria (endemic form)
Immunosuppression
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15
Q

Diagnostic feature of Hodgkin’s disease

A

Reed-Sternberg cells

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16
Q

Treatment of Hodgkin’s disease

A

Radiotherapy and/or chemotherapy

17
Q

Nasopharyngeal carcinoma

A

Epithelial cell cancer originating in the nasopharynx

18
Q

Post-transplantation lymphoproliferative disorder (PTLD)

A

Abnormal proliferation of lymphoid cells in transplant patient

19
Q

PTLD diagnosis

A

Histological analysis of tissue

EBV infection at time of transplant is the major risk factor, so detection of EBV genome via in situ hybridization

20
Q

PTLD treatment

A

Reduce immunosuppression
Rituximab

Conventional chemotherapy

Micro 5 (8 decks)

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