export_circulatory viruses i only ebv Flashcards
EBV diseases
Mono
Oral hairy leukoplakia
Burkitt’s lymphoma
Hodgkin’s disease
Nasopharyngeal carcinoma
PTLD
EBV virus family and features
Herpesviridae
Enveloped, dsDNA
Uses C3d component of complement for attachment and entry, replicates within epithelial and B cells
Latent membrane protein 1
6 transmembrane-spanning domains
CD40 homologue
Constitutively active receptor
Increased growth and suppressed apoptosis
Latent membrane protein 2
Increased growth of B cells
Epstein Barr virus nuclear Ag 1
Transactivation of EBV transforming genes
Inhibit apoptosis
Mono symptoms
Fever, malaise, splenomegaly
Biochemical marker of mono
Heterophile Abs
Pathogenesis of mono
Immune targeting of infected B cells
Mono diagnosis
Mono spot test (RBC agglutination)
Abs to EBV (IgM to viral capsid Ag)
Downey cells
Treatment of mono
Rest and hydration
Avoiding strenuous activity (splenic rupture)
Oral hairy leukoplakia
Typically in immunocompromised individuals
Active EBV replication
Oral hairy leukoplakia treatment
Antiherpetic drugs
Podophyllin resin
Cause of Burkitt’s lymphoma
Genetic translocation of MYC gene into Ig gene resulting in high levels of MYC in these B cells
Highly associated with EBV
Co-factors for Burkitt’s lymphoma
Chronic malaria (endemic form) Immunosuppression
Diagnostic feature of Hodgkin’s disease
Reed-Sternberg cells
Treatment of Hodgkin’s disease
Radiotherapy and/or chemotherapy
Nasopharyngeal carcinoma
Epithelial cell cancer originating in the nasopharynx
Post-transplantation lymphoproliferative disorder (PTLD)
Abnormal proliferation of lymphoid cells in transplant patient
PTLD diagnosis
Histological analysis of tissue
EBV infection at time of transplant is the major risk factor, so detection of EBV genome via in situ hybridization
PTLD treatment
Reduce immunosuppression
Rituximab
Conventional chemotherapy
