Exp 6.2: Lipids (Classifications) Flashcards
Type of Lipid:
Group of signal lipids
Eicosanoids
Type of Lipid:
Derived from metabolism of arachidonic acid by enzyme cyclooxygenase (COX)
Eicosanoids
3 subtypes of eicosanoids
Prostaglandins
Thromboxanes
Leukotrienes
Type of Lipid:
Derived mainly from arachidonic acid
Eicosanoids
Subtype of Eicosanoids:
Have a variety of potent biological activities of hormonal or regulatory nature
Prostaglandins
Subtype of Eicosanoids:
parent compound of prostaglandins
Prostanoic acid
Subtype of Eicosanoids:
Control blood pressure
Prostaglandins
Subtype of Eicosanoids:
Stimulate muscle contraction
Prostaglandins
Subtype of Eicosanoids:
Inhibit platelet aggregation
Prostaglandins
Subtype of Eicosanoids:
Induce inflammation
Prostaglandins
Subtype of Eicosanoids:
Platelet aggregation and vasoconstriction
Thromboxane A2
Subtype of Eicosanoids:
Inhibit the synthesis of thromboxane by inhibiting the COX enzyme
Aspirin and other NSAIDs (Thromboxanes)
Subtype of Eicosanoids:
Synthesized from arachidonic acid
Leukotrienes
Subtype of Eicosanoids:
Occur mainly in leukocytes
Leukotrienes
Subtype of Eicosanoids:
Produce muscle contractions
o Lungs
o Cause asthma-like attacks
Leukotrienes
Subtype of Eicosanoids:
Recently developed anti-asthma drugs
o Inhibit the synthesis of ____________
Leukotrienes
Type of Lipid:
Comprise the bulk of storage fat
glycerolipids
Type of Lipid:
Mono-, di- and tri- substituted glycerols
glycerolipids
1 Subtype of glycerolipids
Triacylglycerols
Subtype of Glycerolipids:
Lipids formed by esterification of three fatty acids to glycerol
Triacylglycerols
Subtype of Glycerolipids:
Neutral lipid
Triacylglycerols
2 subtypes of glycerophospholipids
Phosphoacylglycerol
Phosphatidylcholine (lecithin)
Subtype of Glycerophospholipids:
Most abundant lipid in most membranes
Phosphoacylglycerol
Subtype of Glycerophospholipids:
Polar head and two nonpolar tails
Phosphoacylglycerol
Subtype of Glycerophospholipids:
Control cell permeability
Phosphoacylglycerol
Subtype of Glycerophospholipids:
Abundant in brain and nerve tissues
Phosphatidylcholine (lecithin)
Subtype of Glycerophospholipids:
Found in egg yolk, wheat germ, yeast
Phosphatidylcholine (lecithin)
Type of Lipid:
Second large class of membrane lipids
Sphingolipids
Type of Lipid:
Have a polar head and two nonpolar tails
Sphingolipids
2 subtypes of sphingolipids
Sphingomyelin
Glycolipids
Subtype of sphingolipids:
Contain phosphocholine or phosphoethanolamine as their polar head
Sphingomyelin
Subtype of sphingolipids:
Found in the myelin sheath
Sphingomyelin
Subtype of sphingolipids:
Carbohydrate is bound to an alcohol group of a lipid by a glycosidic linkage
Glycolipids
Type of Lipid:
Sterol alcohols
Sterol lipids
Type of Lipid:
Signaling molecules located along the membrane
Sterol lipids
2 subtypes of sterol lipids
Steroids
Cholesterol
Subtype of sterol lipids:
Contains aromatic alcohol which are derivatives of steroid nucleus
Steroids
Subtype of sterol lipids:
nucleus
o 3 cyclohexane rings
o 1 cyclopentane ring
Steroids
Subtype of sterol lipids:
Precursor for the synthesis of other steroids
Cholesterol
Subtype of sterol lipids:
Weakly amphipathic
Cholesterol
Subtype of sterol lipids:
Cholesteryl esters
o Formed by esterified C3-OH
o Bulky and rigid and fits into membrane lipids disrupting membrane regularity
Cholesterol
Other lipids:
Isoprenoids
Prenol lipids
Other lipids:
Examples : Terpenes, carotenoids, quinones, hydroquinone
Prenol lipids
Other lipids:
Polyprenols (dolichol)
Prenol lipids
Other lipids:
Isoprene derived natural metabolites
Terpenes (Prenol lipid)
Other lipids:
Insect and plant growth hormones
Terpenes (Prenol lipid)
Other lipids:
Plant’s pleasant odors
Terpenes (Prenol lipid)
Other lipids:
Lipid-like sugar carriers
Terpenes (Prenol lipid)
Other lipids:
Fatty acid with a sugar backbone
Saccharolipids
Other lipids:
Glucosamine precursor
Saccharolipids
Other lipids:
Secondary metabolites of living organisms for survival
Polyketides
Other lipids:
Used as anti-microbial, anti-parasitic and anti-cancer
Polyketides
Other lipids:
Doxycycline (antibiotic) and aflatoxin (known carcinogen)
Polyketides
Other lipids:
Esters of fatty acids with long chain alcohols
Waxes
Other lipids:
Waxes’ solubility in water
Completely insoluble in water
Other lipids:
Water repellants
Waxes
Other lipids:
protective coating of leaves composition
Waxes