Exotoxin Stuff Flashcards
Bacteria that make neuro exotoxins
Tetanus- Lock jaw, inhibit GABA release
Botulinun- Floppy Baby
Mechanism of neuro exotoxins
cleave SNARE protein that allows the neurotransmitter to be released
Toxic Shock Syndrome
Staph aureus- TSST, Enterotoxins A-E (vomiting and diarrhea)
Strep Pyognes- Exotoxin A
Both bring MHC II and TCR together, cause overwhelming T cell response
Strep pyogenens exotoxins
Strptolysin O- Oxygen Labile
Streptolysin S- Oxygen Stabile
Erythrogenic/pyrogenic toxins- Scarlett Fever
Remember, Strp pyogenes (Group A strep)
ok
Group B
strep agalactiae
Diptheria
Inactivates EF2, pharyngitis with grey pseudomembranes, very lethal to cardiac and nerve cells
Pseudomonas Aeruginosa also inactivates EF-2 like…
Diptheria
Pseudomonas exotoxin
Exotoxin A
HUS (Hemolytic Uremic Syndrome
CAUSED BY EHEC (Enterohemorrhagic E. coli) Shiga Like Toxin
Hemolytic anemia
Thrombocytopenia
Renal Failure
ETEC exotoxin
Heat labile- inc cAMP which leads to increased cl secretion in gut and water efflux
Heat Stabile- ing cGMP…less resorption of cGMP
Cholera toxin
inc cAMP increases secretion of Cl in gut permanatly, rice water stool
Gas Gangrene
clostridium perfringens…..alpha toxin that degrades tissues and membranes
Whooping cough
Pertussis…..activates cAMP which leads to impairment of phagocytosis of the organism
What exotoxin stimulates adenylate cyclase and leads to increased chlorine and water in the gut
cholera toxina na dheat labile E coli toxin
What toxin inactivates EF-2 and causes pseudomembranous cholitis
Diptheria toxin
What toxin blocks the release of the inhibitory neurotransmitter glycine
Tetani toxin
Organisms that have the ability to activate cAMP
B. Pertussis B. Antracis (edema factor) B. Cereus ETEC (heat labile) Campylobacter Jejuni Vibrio Cholerae
Inc cAMP increases the secretion of sodium, chloride and water
EF-2 disrupters
Diptheria toxin and exotoxin A of pseudomonas
Cytoskeleton disrupter
Clostridium Dificil
Increase level of cGMP
ETEC, Yersinia Pestis
