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Microbiology > Exotoxin Stuff > Flashcards

Exotoxin Stuff Flashcards

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1
Q

Bacteria that make neuro exotoxins

A

Tetanus- Lock jaw, inhibit GABA release

Botulinun- Floppy Baby

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2
Q

Mechanism of neuro exotoxins

A

cleave SNARE protein that allows the neurotransmitter to be released

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3
Q

Toxic Shock Syndrome

A

Staph aureus- TSST, Enterotoxins A-E (vomiting and diarrhea)

Strep Pyognes- Exotoxin A

Both bring MHC II and TCR together, cause overwhelming T cell response

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4
Q

Strep pyogenens exotoxins

A

Strptolysin O- Oxygen Labile
Streptolysin S- Oxygen Stabile
Erythrogenic/pyrogenic toxins- Scarlett Fever

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5
Q

Remember, Strp pyogenes (Group A strep)

A

ok

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6
Q

Group B

A

strep agalactiae

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7
Q

Diptheria

A

Inactivates EF2, pharyngitis with grey pseudomembranes, very lethal to cardiac and nerve cells

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8
Q

Pseudomonas Aeruginosa also inactivates EF-2 like…

A

Diptheria

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9
Q

Pseudomonas exotoxin

A

Exotoxin A

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10
Q

HUS (Hemolytic Uremic Syndrome

A

CAUSED BY EHEC (Enterohemorrhagic E. coli) Shiga Like Toxin

Hemolytic anemia
Thrombocytopenia
Renal Failure

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11
Q

ETEC exotoxin

A

Heat labile- inc cAMP which leads to increased cl secretion in gut and water efflux

Heat Stabile- ing cGMP…less resorption of cGMP

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12
Q

Cholera toxin

A

inc cAMP increases secretion of Cl in gut permanatly, rice water stool

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13
Q

Gas Gangrene

A

clostridium perfringens…..alpha toxin that degrades tissues and membranes

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14
Q

Whooping cough

A

Pertussis…..activates cAMP which leads to impairment of phagocytosis of the organism

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15
Q

What exotoxin stimulates adenylate cyclase and leads to increased chlorine and water in the gut

A

cholera toxina na dheat labile E coli toxin

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16
Q

What toxin inactivates EF-2 and causes pseudomembranous cholitis

A

Diptheria toxin

17
Q

What toxin blocks the release of the inhibitory neurotransmitter glycine

A

Tetani toxin

18
Q

Organisms that have the ability to activate cAMP

A 
B. Pertussis
B. Antracis (edema factor)
B. Cereus
ETEC (heat labile)
Campylobacter Jejuni
Vibrio Cholerae

Inc cAMP increases the secretion of sodium, chloride and water

19
Q

EF-2 disrupters

A

Diptheria toxin and exotoxin A of pseudomonas

20
Q

Cytoskeleton disrupter

A

Clostridium Dificil

21
Q

Increase level of cGMP

A

ETEC, Yersinia Pestis

Microbiology (11 decks)

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