Exley cell signalling lecture 2 Flashcards
What is a stereoisomer?
Molecules having the same kind and number of atoms though in a different three-dimensional arrangement or configuration.
What is a stereoisomer?
Molecules having the same kind and number of atoms though in a different three-dimensional arrangement or configuration.
Where is most of the inositol biosynthesised in the body?
about 4g in the kidney
Where is inositol degraded?
By what enzyme?
What is the product?
- Kidney and liver
- myo-inositol oxygenase
- Myo-inositol -> D-glucuronate -> D-xylose 5-phosphate
Conc of inositol in:
1) plasma
2) cerebrospinal fluid
3) brain
4) inside neurones and glia
Plasma = 0.03mM
Cerebrospinal fluid = 0.2mM
Brain = 6mM
Neurones/glia = 10-20mM
What are the main roles of inositol in the CNS?
1) Precurser to the synthesis of inositol phospholipids (intracellular signalling mechanisms)
2) Regulates cell volume (osmolyte)
What does PI stand for?
Phosphatidylinositol phosphate
What part of the cell are inositol phosphates found?
cell cytosol
Where is most of the inositol biosynthesised in the body?
about 4g in the kidney
Where is inositol degraded?
By what enzyme?
What is the product?
- Kidney and liver
- myo-inositol oxygenase
- Myo-inositol -> D-glucuronate -> D-xylose 5-phosphate
Conc of inositol in:
1) plasma
2) cerebrospinal fluid
3) brain
4) inside neurones and glia
Plasma = 0.03mM
Cerebrospinal fluid = 0.2mM
Brain = 6mM
Neurones/glia = 10-20mM
What are the main roles of inositol in the CNS?
1) Precurser to the synthesis of inositol phospholipids (intracellular signalling mechanisms)
2) Regulates cell volume (osmolyte)
What does PI stand for?
Phosphatidylinositol phosphate
What part of the cell are inositol phosphates found?
cell cytosol
