Excretion

Question 1

Correct definition of clearance is:

A. Clearance is the volume of any organ in body cleared of drug per unit of time.
B. Clearance is the volume of blood/plasma cleared of drug per unit of time.
C. The volume of blood or any organ where the drug can be found.
D. The amount of drug eliminating from the body per unit of time.

Answer 1

B. Clearance is the Volume of blood/plasma cleared of drug per unit of time.

Question 2

Which is NOT a correct clearance equation?

A. CL=VK
B. CL=QE
C. CL= Dose/concentration
D. CL= Rate/Cp

Answer 2

C. CL=Dose/Concentration

Question 3

Which clearance equation relates to compartment model?

A. CL=VK
B. CL=QE
C. CL=Dose/concentration
D. CL=Rate/Cp

Answer 3

A. CL=VK

Question 4

Main driving force of Glomerular filtration is:

A. Passive diffusion
B. Facilitated diffusion
C. Active transport
D. Hydrostatic pressure

Answer 4

E. Hydrostatic pressure

Question 5

Active tubular secretion is measured by:

A. Para-amino hippuric acid (PAH)
B. Acetaminophen
C. Creatinine
D. Cytochrome P450

Answer 5

A. Para-amino hippuric acid (PAH)

Question 6

Correct definition of clearance is:

A. The volume of body are cleared of drug per unit of time
B. The Volume of blood/plasma cleared of drug per unit of time
C. The amount of drug eliminating from the blood per unit of time
D. The rate at which drug is eliminating from the body

Answer 6

B. The Volume of blood/plasma cleared of drug per unit of time

Question 7

Which is not correct equation for clearance?

A. CL=VK
B. CL=QE
C. CL=Dose/Concentration
D. CL=Rate/Cp

Answer 7

CL=Dose/Concentration

Question 8

Which of the following equation follows the compartment model?

A. CL=QE
B. CL=Rate/Cp
C. CL=VK
D. CL=Dose/AUC

Answer 8

C. CL.VK

Question 9

Which drug is not cleared by kidney (renal clearance)?

A. Non-volatile
B. Water soluble drugs
C. Low molecular weight drug
D. Volatile drug

Answer 9

D. Volatile drug

Question 10

Which is not a part of renal clearance process?

A. Glomerular filtration
B. Active transportation
C. Tubular Reabsorption
D. Active tubular secretion

Answer 10

B. Active transportation

Question 11

The major driving force for glomerular filtration is:

A. Hydrostatic pressure
B. Active transporter
C. Passive diffusion
D. Osmotic pressure

Answer 11

A. Hydrostatic pressure

Question 12

Active tubular secretion is measured by:

A. Cytochrome P450
B. Insulin
C. Creatinine
D. Para-amino hippuric acid (PAH)

Answer 12

D. Para amino hippuric acid (PAH)

Question 13

Creating is reliable indicator of:

A. Kidney function
B. Liver function
C. Heart function
D. Brain function

Answer 13

A. kidney function

Question 14

Organ clearance is determined by ______________ and ____________.

Answer 14

Q and E

Question 15

The study of the time course of drug absorption, distribution, metabolism, and excretion is called:

A. pharmacodynamics.
B. drug concentration.
C. pharmacokinetics.
D. kinetic homogeneity

Answer 15

C. Pharmacokinetics

Question 16

The EC50 refers to the drug concentration at which:

A. one-half the maximum response is achieved.
B. the maximal effect is achieved.
C. tolerance is likely to be observed.

Answer 16

A. One-half the maximum response is achieved

Question 17

For a drug with a narrow therapeutic index, the plasma concentration required for therapeutic effects is near the concentration that produces toxic effects.

A. True
B. False

Answer 17

A. True

Question 18

The units for clearance are:

A. concentration/half-life.
B. dose/volume.
C. half-life/dose.
D. volume/time

Answer 18

D. Volume/time

Question 19

Which of the following pharmacokinetic processes are part of “Drug Disposition”? (Select all that apply)

a. excretion
b. metabolism
c. distribution
d. absorption

Answer 19

a. excretion
b. metabolism
c. distribution

Question 20

Drug elimination is divided into two major components: (2)

Answer 20

1. Excretion

2. Biotransformation

Question 21

Is the most important PK parameter.

Answer 21

Clearance