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PHA337 > Absorption > Flashcards

Absorption Flashcards

1
Q

Which the following route of administration has partial first effect?

A. Sublingual
B. Rectal
C. Buccal
D. Oral

A

B. Rectal

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2
Q

Which is true about IV parenteral route of administration?

A. Retrieval of drug is possible
B. This route is non-systematic
C. There is no absorption of drug
D. Always has first pass effect

A

C. There is no absorption of drug

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3
Q

The study of the biochemical and physiological effects of drugs on the body and the mechanisms of drug action and the relationship between drug concentration and effect is studied in which field?

A. Pharmacodynamics
B. Pharmacokinetics
C. Biopharmaceutics
D. Psychokinetics

A

A. Pharmacodynamics

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4
Q

If a weak acidic drug has a pKa of 2.6, in which pH the drug will have higher absorption?

A. 4.3
B. 3.1
C. 2.3
D. 5.2

A

C. 2.3

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5
Q

All of the following physico-chemical factors determine the permeability EXCEPT:

A. Molecular weight
B. Lipophilicity
C. Boiling point
D. Degree of ionization

A

B. Boiling point

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6
Q

The passage of drug from the blood stream into various tissues and organs such as muscle or heart is defined as:

A. Absorption
B. Metabolism
C. Distribution
D. Elimination

A

C. Distribution

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7
Q

A delay in the gastric emptying time for the drug will:

A. Fast the absorption rate
B. Increase the extent of absorption
C. Slow the absorption rate
D. Will cause no change in absorption

A

C. Slow the absorption

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8
Q

Drug absorption may be affected by any disease that causes changes in intestinal blood flow or Gastric emptying.

A. True
B. False

A

A. True

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9
Q

Which route of administration has no absorption phase?

A. Rectal
B. Intra-arterial
C. Trans dermal
D. Oral

A

B. Intra-arterial

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10
Q

At low concentration the active transport of drug follows which order of kinetics?

A. Zero order
B. Second order
C. First order
D. Third order

A

First order

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11
Q

A drug with which molecular weight will have higher permeability through the cell membrane?

A. 552
B. 243
C. 413
D. 354

A

B. 243

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12
Q

If an acidic drug is more unionized, the absorption (or bioavailability) will be higher for that drug.

A. True
B. False

A

A. True

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13
Q 
Which route of administration has first pass effect?
A. Subcuteneous
B. Rectal
C. Sublingual
D. Transdermal
A

B. Rectal

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14
Q

If a week acidic drug has a pKa of 3.4, at what pH the drug will have higher absorption?

A. 3.4
B. 5.2
C. 4.3
D. 2.3

A

D. 2.3

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15
Q

Which type of drug will have comparatively higher permeability through the cell membrane?

A. Lipophilic drug
B. Negatively ionized drug
C. Hydrophilic drug
D. Positively ionized drug

A

A. Lipophilic drug

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16
Q

Weak acids are going to primarily be _______ in the stomach.

A. Absorbed
B. Poorly absorbed

A

A. Absorbed

17
Q

Weak bases are going to primarily be _______ in the small intestine.

A. Absorbed
B. Poorly absorbed

A

A. Absorbed

18
Q

Passive diffusion ________. (3)

A. Involves carriers
B. Does not involve carriers
C. Is saturable
D. Is not saturable
E. Can be inhibited
F. Cannot be inhibited
A

B. Does not involve carriers
D. Is not saturable
F. Cannot be inhibit

19
Q

Active transport ________ (3)

A. Involves carriers
B. Does not involve carriers
C. Is saturable
D. Is not saturable
E. Can be inhibited
F. Cannot be inhibited
A

A. Involves carries
B. Is saturable
C. Can be inhibited

20
Q

Which of the following routes of drug administration contains FIRST-PASS metabolism?

A. oral (PO)
B. inhalation
C. topical
D. IV
E. rectal (PR)
A

A. Oral

E. Rectal (partial)

21
Q

Transdermal route _______

A. encounters the first-pass effect
B. avoids the first-pass effect
C. partially avoids the first-pass effect

A

B. Avoids the first-pass effect

22
Q

The rectal route of drug administration _______

A. encounters the first-pass effect
B. avoids the first-pass effect
C. partially avoids the first-pass effect

A

C. Partially avoids the first-pass effect

23
Q

What has the greatest effect on bioavailability?

A

First-pass effect

PHA337 (5 decks)

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