Distribution

Question 1

Which of the factors DOES NOT affect the volume of distribution?

A. Protein binding
B. Molecular shape
C. Lipophilicity
D. Molecular weigh

Answer 1

B. Molecular shape

Question 2

Apparent volume of distribution is calculated by knowing the drug concentration in:

A. Muscle
B. Fat
C. Blood
D. Whole body

Answer 2

C. Blood

Question 3

Heparin-blood, Warfarin-plasma binding, Ethanol-total body, Chloroquine-fat, which drug will have highest Vd?

A. Heparin
B. Ethanol
C. Warfarin
D. Chloroquine

Answer 3

D. Chloroquine

Question 4

For a drug, if the dose amount is 300mg, and drug concentration was found 0.2mg,ml, what is the Vd?

A. 150mL
B. 1500mL
C. 60mL
D. 600mL

Answer 4

B. 1500mL

Question 5

Unionized fraction at pH7.4; Thiopental 60%, Phenobarbital 80, Barbit 60, Salicylic acid 0.4, which has lowest permeability?

A. Phenobarbital
B. Salicylic Acid
C. Thiopental
D. Barbital

Answer 5

B. Salicylic Acid

Question 6

Drug accumulation in tissue happens due to:

A. Blood flow and molecular weight of the drug
B. Molecular weight and acidity of the drug
C. Molecular weight and affinity of the drug for the tissue.
D. Blood flow and the affinity of the drug for the tissue.

Answer 6

D. Blood flow and the affinity of the drug for the tissue.